ArticleProgress in neurobiology2021
Causal role of cross-frequency coupling in distinct components of cognitive control.
Article in Progress in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Back in time: Reversed speech as a window into cognitive language processing-A systematic review.Psychonomic bulletin & review · 2026Pooled it
- Functional and effective EEG connectivity patterns in Alzheimer's disease and mild cognitive impairment: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- Pooled it
- Triangular Wave tACS Improves Working Memory Performance by Enhancing Brain Activity in the Early Stage of Encoding.Neuroscience bulletin · 2025Trial
- Reduction in Left Frontal Alpha Oscillations by Transcranial Alternating Current Stimulation in Major Depressive Disorder Is Context Dependent in a Randomized Clinical Trial.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Trial
- Causal role of frontal-midline theta in cognitive effort: a pilot study.Journal of neurophysiology · 2021Trial
- Insights into the neural mechanisms supporting cognitive stability and flexibility from human intracranial electroencephalography.Neuroscience and biobehavioral reviews · 2026Review
- Modulation of prefrontal theta oscillations slows social cognition.Cognitive, affective & behavioral neuroscience · 2026Article
- Visual Perception and Gamma Oscillations in Cat V1 are Dynamically Correlated in Contrast Sensitivity Functions.Neuroscience bulletin · 2026Article
- Closed-loop transcranial alternating current stimulation (tACS) reduces cue reactivity and improves inhibitory control in methamphetamine use disorder with frequency and timing specificity.Molecular psychiatry · 2026Article
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Distinct neural oscillations predict individual differences in feedback-guided cognitive flexibility.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Causal Evidence for Prefrontal-Motor Coupling in Reward-Responsive Goal-Directed Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Emotional information recruits specific neural dynamics to support hierarchical cognitive control.Social cognitive and affective neuroscience · 2026Article
- Prefrontal Hierarchical Control of Corticomuscular Coherence in Stroke.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Resonant hierarchies: a multiscale framework for oscillatory dynamics in the brain.Frontiers in psychology · 2026Article
- Visual Neural Dynamics of Adolescents with Myopia During Face Inversion: An ERP and Oscillatory Study.Brain sciences · 2025Article
- Attenuated theta-band activity and cross-frequency coupling in schizophrenia during affective response inhibition.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Mapping EEG Metrics to Human Affective and Cognitive Models: An Interdisciplinary Scoping Review from a Cognitive Neuroscience Perspective.Biomimetics (Basel, Switzerland) · 2025Review
- Augmenting single-session behavioral activation for depression with delta-beta tACS: Preliminary investigation of a double-blind placebo-controlled randomized pilot clinical trial.Journal of mood and anxiety disorders · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Cognitive control is the capacity to guide motor and perceptual systems towards abstract goals. High-frequency neural oscillations related to motor activity in the beta band (13-30 Hz) and to visual processing in the gamma band (>30 Hz) are known to be modulated by cognitive control signals. One proposed mechanism for cognitive control is via cross-frequency coupling whereby low frequency network oscillations in prefrontal cortex (delta from 2-3 Hz and theta from 4-8 Hz) guide the expression of motor-related activity in action planning and guide perception-related activity in memory access. However, there is no causal evidence for cross-frequency coupling in these dissociable components of cognitive control. To address this important gap in knowledge, we delivered cross-frequency transcranial alternating current stimulation (CF-tACS) during performance of a task that manipulated cognitive control demands along two dimensions: the abstraction of the rules of the task (nested levels of action selection) that increased delta-beta coupling and the number of rules (set-size held in memory) that increased theta-gamma coupling. As hypothesized, we found that CF-tACS increased the targeted phase-amplitude coupling and modulated task performance of the associated cognitive control component. These findings provide causal evidence that prefrontal cortex orchestrates different components of cognitive control via two different cross-frequency coupling modalities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.