ArticleInternational dental journal2021
Association Between the Extent of Periodontal Inflammation and the Severity of Rheumatoid Arthritis in Japanese Patients With Rheumatoid Arthritis.
Article in International dental journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Clinical analysis of osteonecrosis of the jaw in patients with rheumatoid arthritis: risk factors and oral health implications.Clinical rheumatology · 2026Article
- Histological analysis of periodontal tissues in patients with autoimmune diseases: a comparative cross-sectional study of inflammatory cell infiltration and epithelial barrier function.BMC oral health · 2026Article
- Synovial macrophages drive severe joint destruction in established rheumatoid arthritis.Scientific reports · 2025Article
- Immunological landscape of periodontitis and rheumatoid arthritis and their molecular crosstalk.European journal of medical research · 2025Article
- Synoviocyte detachment: an overlooked yet crucial histological aspect in rheumatoid arthritis.BMC musculoskeletal disorders · 2024Article
- Periodontitis and periodontopathic bacteria as risk factors for rheumatoid arthritis: A review of the last 10 years.The Japanese dental science review · 2023Review
- Periodontal Inflamed Surface Area (PISA) associates with composites of salivary cytokines.PloS one · 2023Article
- Functional Impairment and Periodontitis in Rheumatoid Arthritis.International dental journal · 2022Article
- Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study.Scientific reports · 2021Article
- Comparison of periodontal parameters between patients with ischemic and dilative cardiomyopathy.BMC cardiovascular disorders · 2021Article
- PISA: Inflamed Surface Area of Gums Triggering Systemic Hyperinflammation.Journal of mid-life healthReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePeriodontal inflammation can affect the progression of rheumatoid arthritis (RA), and RA drugs may influence the periodontal condition of patients with RA. We examined whether the association between periodontal inflammation and the severity of RA is influenced by RA medication.
methodsThis cross-sectional study recruited 98 Japanese patients with RA from an orthopaedic clinic. We assessed the severity of RA using the Steinbrocker class and stage. The periodontal inflamed surface area (PISA) was used as an indicator of periodontal status. We obtained data on RA medications from medical records. We examined the associations among periodontal tissue inflammation, RA medications, and RA severity using multinomial logistic regression analyses.
resultsIn univariate multinomial logistic regression analyses, no significant association between PISA score and RA severity was observed. There was no significant association between PISA score and RA severity in multivariate analyses not including variables about RA drugs as independent variables. However, in multivariate analyses adjusted for RA drugs and other confounding variables, patients with a PISA >550 mm
conclusionThe extent of periodontal inflammation is associated with the severity of RA independent of RA medications.
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