Evidence map›Paper›PMID 33741002›Full record

ArticleJournal of nanobiotechnology2021

Micro/nano-textured hierarchical titanium topography promotes exosome biogenesis and secretion to improve osseointegration.

Zhengchuan Zhang, Ruogu Xu, Yang Yang, Chaoan Liang, Xiaolin Yu, Yun Liu, Tianlu Wang, Yi Yu, Feilong Deng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 72 citations in OpenAlex.

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  8. Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zhengchuan Zhang *Department of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, No.56 of LingYuanXiLu, Guangzhou, 510055, Guangdong, People's Republic of China.
Ruogu Xu *Department of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, No.56 of LingYuanXiLu, Guangzhou, 510055, Guangdong, People's Republic of China.
Yang YangDepartment of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, No.56 of LingYuanXiLu, Guangzhou, 510055, Guangdong, People's Republic of China.
Chaoan LiangDepartment of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, No.56 of LingYuanXiLu, Guangzhou, 510055, Guangdong, People's Republic of China.
Xiaolin YuDepartment of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, No.56 of LingYuanXiLu, Guangzhou, 510055, Guangdong, People's Republic of China.
Yun LiuDepartment of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, No.56 of LingYuanXiLu, Guangzhou, 510055, Guangdong, People's Republic of China.
Tianlu WangDepartment of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, No.56 of LingYuanXiLu, Guangzhou, 510055, Guangdong, People's Republic of China.
Yi YuDepartment of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, No.56 of LingYuanXiLu, Guangzhou, 510055, Guangdong, People's Republic of China.
Feilong DengDepartment of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, No.56 of LingYuanXiLu, Guangzhou, 510055, Guangdong, People's Republic of China. dengfl@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-6848-4174
Stomatology Hospital · CNKey Laboratory of Guangdong Province · CN

Funding

Guangdong Provincial Science and Technology Major Project No. 2017B090912004
6 · The paper itself

Abstract

backgroundMicro/nano-textured hierarchical titanium topography is more bioactive and biomimetic than smooth, micro-textured or nano-textured titanium topographies. Bone marrow mesenchymal stem cells (BMSCs) and exosomes derived from BMSCs play important roles in the osseointegration of titanium implants, but the effects and mechanisms of titanium topography on BMSCs-derived exosome secretion are still unclear. This study determined whether the secretion behavior of exosomes derived from BMSCs is differently affected by different titanium topographies both in vitro and in vivo.

resultsWe found that both micro/nanonet-textured hierarchical titanium topography and micro/nanotube-textured hierarchical titanium topography showed favorable roughness and hydrophilicity. These two micro/nano-textured hierarchical titanium topographies enhanced the spreading areas of BMSCs on the titanium surface with stronger promotion of BMSCs proliferation in vitro. Compared to micro-textured titanium topography, micro/nano-textured hierarchical titanium topography significantly enhanced osseointegration in vivo and promoted BMSCs to synthesize and transport exosomes and then release these exosomes into the extracellular environment both in vitro and in vivo. Moreover, micro/nanonet-textured hierarchical titanium topography promoted exosome secretion by upregulating RAB27B and SMPD3 gene expression and micro/nanotube-textured hierarchical titanium topography promoted exosome secretion due to the strongest enhancement in cell proliferation.

conclusionsThese findings provide evidence that micro/nano-textured hierarchical titanium topography promotes exosome biogenesis and extracellular secretion for enhanced osseointegration. Our findings also highlight that the optimized titanium topography can increase exosome secretion from BMSCs, which may promote osseointegration of titanium implants.

Indexed as

ExosomesOsseointegrationAnimalsCell DifferentiationCell ProliferationCell SurvivalHumansMaleMesenchymal Stem CellsNanotechnologyNanotubesOsteogenesisProstheses and ImplantsRatsSurface PropertiesTitaniumTitaniumBone marrow mesenchymal stem cellsExosomesMicro/nanonet-textured hierarchical titanium topographyMicro/nanotube-textured hierarchical titanium topographyOsseointegration

Identifiers

PMID33741002
PMCPMC7980346
OpenAlexW3138527570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.