ArticleBMC oral health2021
Tooth mousse containing casein phosphopeptide-amorphous calcium phosphate prevents biofilm formation of Streptococcus mutans.
Article in BMC oral health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Effect of intensive application of self-assembling peptide P11-4 with fluoride, casein phosphopeptide amorphous calcium phosphate fluoride and sodium fluoride on streptococcus mutans level in preschool children: a randomized controlled clinical trial.Clinical oral investigations · 2025Trial
- Protective and remineralizing capacity of biosilicate, chitosan-based material, and fluoride on demineralized and irradiated enamel.Radiation and environmental biophysics · 2026Article
- Article
- Drug repurposing for glucosyltransferase inhibition for targeted oral biofilm disruption.NPJ biofilms and microbiomes · 2026Article
- AnInternational journal of clinical pediatric dentistry · 2026Article
- Investigating the effect of casein phosphopeptide-amorphous calcium phosphate, fluoride varnish, and diode laser on enamel microhardness.Dental research journal · 2026Article
- In vitro evaluation of the effects of various remineralization agents on root caries.BMC oral health · 2025Article
- Mechanism of Action of Zinc Oxide Nanoparticles as an Antibacterial Agent AgainstBiomolecules · 2025Article
- Comparative Evaluation of Remineralization Potential of Various Fluoride Varnishes in Primary Teeth.Journal of pharmacy & bioallied sciences · 2025Article
- Remineralization of Enamel Using Topical Agents among Patients with Orthodontic Brackets:International journal of clinical pediatric dentistry · 2024Article
- Effect of medicated toothpastes and Tooth Mousse on cariogenic microbes of the oral cavity: AnJournal of conservative dentistry and endodontics · 2024Article
- Article
- Article
- Anti-Bacterial and Anti-Biofilm Activities of Anandamide against the CariogenicInternational journal of molecular sciences · 2023Article
- Biocompatibility and osteoinductive ability of casein phosphopeptide modified polyetheretherketone.Frontiers in bioengineering and biotechnology · 2023Article
- Anti-Bacterial Effect of Cannabidiol against the CariogenicInternational journal of molecular sciences · 2022Article
- Review
- Targeting the Achilles' Heel of Multidrug-ResistantInternational journal of molecular sciences · 2022Article
- Anti-Biofilm Activity of Cannabigerol againstMicroorganisms · 2021Article
- Effect of epigallocatechin gallate on dental biofilm of Streptococcus mutans: An in vitro study.BMC oral health · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStreptococcus mutans is a common cariogenic bacterium in the oral cavity involved in plaque formation. Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) has been introduced into tooth mousse to encourage remineralization of dental enamel. The aim of this research was to study the effect of tooth mousse containing CPP-ACP (GC Tooth Mousse®) or CPP-ACP with 0.2% fluoride (CPP-ACPF; GC Tooth Mousse Plus®; GCP) on S. mutans planktonic growth and biofilm formation.
methodsS. mutans was cultivated in the presence of different dilutions of the tooth mousse containing CPP-ACP or CPP-ACPF, and the planktonic growth was determined by ATP viability assay and counting colony-forming units (CFUs). The resulting biofilms were examined by crystal violet staining, MTT metabolic assay, confocal laser scanning microscopy (CLSM), and scanning electron microscope (SEM).
resultsThe CPP-ACP tooth mousse (GC) at a dilution of 5-50 mg/ml (0.5-5%) did not inhibit planktonic growth, and even increased the ATP content and the number of viable bacteria after a 24 h incubation. The same was observed for the CPP-ACPF tooth mousse (GCP), except for the higher concentrations (25 and 50 mg/ml) that led to a drop in the bacterial count. Importantly, both compounds significantly decreased S. mutans biofilm formation at dilutions as low as 1.5-3 mg/ml. 12.5 mg/ml GC and 6.25 mg/ml GCP inhibited biofilm formation by 90% after 4 h. After 24 h, the MBIC
conclusionOur data show that the tooth mousse containing CPP-ACP reduces biofilm formation of the cariogenic bacterium S. mutans without killing the bacteria. The use of natural substances which inhibit biofilm development without killing the bacteria, has therapeutic benefits, especially in orthodontic pediatric patients.
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