ArticleBMC biology2021
Long-term persistence of supernumerary B chromosomes in multiple species of Astyanax fish.
Article in BMC biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Molecular divergence and genomic composition of B chromosomes in the fish Cyphocharax modestus (Characiformes, Curimatidae).Scientific reports · 2026Article
- An intraspecific origin of B chromosomes in Tetragonisca fiebrigi (Apidae: Meliponini) inferred from cytogenetic and nuclear genome size data.Scientific reports · 2026Article
- Article
- Cytogenetics of Neotropical fishes: Patterns, advances and prospects after five decades of research.Genetics and molecular biology · 2026Article
- What is a B chromosome? Early definitions revisited.G3 (Bethesda, Md.) · 2024Article
- Article
- B Chromosomes inAnimals : an open access journal from MDPI · 2022Review
- Meiotic self-pairing of the Psalidodon (Characiformes, Characidae) iso-B chromosome: A successful perpetuation mechanism.Genetics and molecular biology · 2021Article
- Satellite DNA Is an Inseparable Fellow Traveler of B Chromosomes.Progress in molecular and subcellular biology · 2021Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundEukaryote genomes frequently harbor supernumerary B chromosomes in addition to the "standard" A chromosome set. B chromosomes are thought to arise as byproducts of genome rearrangements and have mostly been considered intraspecific oddities. However, their evolutionary transcendence beyond species level has remained untested.
resultsHere we reveal that the large metacentric B chromosomes reported in several fish species of the genus Astyanax arose in a common ancestor at least 4 million years ago. We generated transcriptomes of A. scabripinnis and A. paranae 0B and 1B individuals and used these assemblies as a reference for mapping all gDNA and RNA libraries to quantify coverage differences between B-lacking and B-carrying genomes. We show that the B chromosomes of A. scabripinnis and A. paranae share 19 protein-coding genes, of which 14 and 11 were also present in the B chromosomes of A. bockmanni and A. fasciatus, respectively. Our search for B-specific single-nucleotide polymorphisms (SNPs) identified the presence of B-derived transcripts in B-carrying ovaries, 80% of which belonged to nobox, a gene involved in oogenesis regulation. Importantly, the B chromosome nobox paralog is expressed > 30× more than the A chromosome paralog. This indicates that the normal regulation of this gene is altered in B-carrying females, which could potentially facilitate B inheritance at higher rates than Mendelian law prediction.
conclusionsTaken together, our results demonstrate the long-term survival of B chromosomes despite their lack of regular pairing and segregation during meiosis and that they can endure episodes of population divergence leading to species formation.
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