Evidence map›Paper›PMID 33740885›Full record

Observational studyBMC anesthesiology2021

The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients - a posthoc propensity score-weighted cohort analysis of the LAS VEGAS study.

Guido Mazzinari, Ary Serpa Neto, Sabrine N T Hemmes, Goran Hedenstierna, Samir Jaber, Michael Hiesmayr, Markus W Hollmann, Gary H Mills, Marcos F Vidal Melo, Rupert M Pearse and 12 more

2 registry-linked trialsOpen access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in BMC anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01601223 completednot on this map

Local Assessment of Ventilatory Management During General Anesthesia for Surgery - a Prospective Observational Multi-center Cohort Study

TypeobservationalSponsorEuropean Society of AnaesthesiologyRan2013 to 2013Enrolled10,690ConditionsSurgery, Anaesthesia, Ventilator-Induced Lung Injury, Lung Injury
NCT07728214 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Reminder-enhanced Incentive Spirometry Evaluation (RISE)

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2029Enrolled88ConditionsHypoxemiaArmsAlarms ON
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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  10. [Anesthesia for robot-assisted surgery].Die Anaesthesiologie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 12 institutions in 11 countries.

Guido MazzinariResearch Group in Perioperative Medicine, Hospital Universitario y Politécnico la Fe, Avinguda de Fernando Abril Martorell 106, 46026, Valencia, Spain. gmazzinari@gmail.com.
Ary Serpa NetoDepartment of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Sabrine N T HemmesDepartment of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, Amsterdam, The Netherlands.
Goran HedenstiernaDepartment of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
Samir JaberPhyMedExp, INSERM U1046, CNRS UMR 9214, University of Montpellier, Montpellier, France.
Michael HiesmayrDivision Cardiac, Thoracic, Vascular Anesthesia and Intensive Care, Medical University Vienna, Vienna, Austria.
Markus W HollmannDepartment of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, Amsterdam, The Netherlands.
Gary H MillsOperating Services, Critical Care and Anesthesia, Sheffield Teaching Hospitals, Sheffield and University of Sheffield, Sheffield, UK.
Marcos F Vidal MeloDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, USA.
Rupert M PearseQueen Mary University of London, London, UK.
Christian PutensenDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
Werner SchmidDivision Cardiac, Thoracic, Vascular Anesthesia and Intensive Care, Medical University Vienna, Vienna, Austria.
Paolo SevergniniDepartment of Biotechnology and Sciences of Life, ASST- Settelaghi Ospedale di Circolo e Fondazione Macchi, University of Insubria, Varese, Italy.
Hermann WriggeDepartment of Anesthesiology, Intensive Care and Emergency Medicine, Pain Therapy, Bergmannstrost Hospital, Halle, Germany.
Oscar Diaz CambroneroResearch Group in Perioperative Medicine, Hospital Universitario y Politécnico la Fe, Avinguda de Fernando Abril Martorell 106, 46026, Valencia, Spain.
Lorenzo BallPoliclinico San Martino Hospital - IRCCS for Oncology and Neurosciences, Genoa, Italy.
Marcelo Gama de AbreuDepartment of Anesthesiology and Intensive Care Therapy, Pulmonary Engineering Group, Technische Universität Dresden, Dresden, Germany.
Paolo PelosiPoliclinico San Martino Hospital - IRCCS for Oncology and Neurosciences, Genoa, Italy.
Marcus J SchultzDepartment of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, Amsterdam, The Netherlands.
LAS VEGAS study–investigators
PROtective VEntilation NETwork
Clinical Trial Network of the European Society of Anaesthesiology
Ospedale Policlinico San Martino · ITAmsterdam UMC Location University of Amsterdam · NLCentre National de la Recherche Scientifique · FRHospital Universitari i Politècnic La Fe · ESMahidol University · THQueen Mary University of London · GBUniversity of Insubria · ITUppsala University · SEBG Klinikum Bergmannstrost Halle · DEHospital Israelita Albert Einstein · BRSheffield Teaching Hospitals NHS Foundation Trust · GBUniversity Hospital Bonn · DE

Funding

1/2: An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR StudyUH3HL140177 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FERNANDEZ-BUSTAMANTE, ANA, VIDAL MELO, MARCOS F · 2020 to 2023
$6.6M
NHLBI NIH HHS UH3 HL140177
6 · The paper itself

Abstract

backgroundIt is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time-weighted average ΔP (ΔP

methodsPosthoc retrospective propensity score-weighted cohort analysis of patients undergoing open or closed abdominal surgery in the 'Local ASsessment of Ventilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs. The secondary endpoint was a composite of intraoperative adverse events.

resultsThe analysis included 1128 and 906 patients undergoing open or closed abdominal surgery, respectively. The PPC rate was 5%. ΔP was lower in open abdominal surgery patients, but ΔP

conclusionsΔP is associated with PPC and intraoperative adverse events in abdominal surgery, both in open and closed abdominal surgery.

trial registrationLAS VEGAS was registered at clinicaltrials.gov (trial identifier NCT01601223 ).

Indexed as

LaparoscopyAbdomenAdultAgedAnesthesia, GeneralCohort StudiesFemaleHumansLung DiseasesMaleMiddle AgedPositive-Pressure RespirationPostoperative ComplicationsPropensity ScoreRespiration, ArtificialRetrospective StudiesDriving pressureLaparoscopic surgeryLaparoscopyPEEPPerioperative ventilationPneumoperitoneumProtective ventilationRespiratory mechanics

Identifiers

PMID33740885
PMCPMC7977277
OpenAlexW3137268756

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.