Evidence map›Paper›PMID 33740456›Full record

ArticleCell2021

SnapShot: Neurobiology of opioid use disorder.

Randall J Ellis, Tanni Rahman, Jeremy Sherman, Yasmin L Hurd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Epigenetic mechanisms of HIV and opioid-induced neuropathology: Potential therapies and interventions.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  2. Differential expression ofDrug and alcohol dependence reports · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Randall J EllisDepartments of Neuroscience and Psychiatry, Icahn School of Medicine at Mount Sinai, Addiction Institute of Mount Sinai, New York, NY, USA.
Tanni RahmanDepartments of Neuroscience and Psychiatry, Icahn School of Medicine at Mount Sinai, Addiction Institute of Mount Sinai, New York, NY, USA.
Jeremy ShermanDepartments of Neuroscience and Psychiatry, Icahn School of Medicine at Mount Sinai, Addiction Institute of Mount Sinai, New York, NY, USA.
Yasmin L HurdDepartments of Neuroscience and Psychiatry, Icahn School of Medicine at Mount Sinai, Addiction Institute of Mount Sinai, New York, NY, USA.

Funding

TRANSGENIC COREP01DA008227 · NIDA · YALE UNIVERSITY · PI NESTLER, ERIC J. · 1993 to 2018
$28.1M
The Opioid mesolimbic system in heroin abuseR01DA015446 · NIDA · KAROLINSKA INSTITUTE · PI HURD, YASMIN L. · 2002 to 2018
$7.1M
Molecular Neurobiology of Human Opioid Use DisorderR01DA051191 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HURD, YASMIN L. · 2021 to 2025
$2.9M
Molecular Neurobiology of Human Drug AbuseR56DA015446 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HURD, YASMIN L. · 2019 to 2019
$564k
NIDA NIH HHS P01 DA008227NIDA NIH HHS R01 DA015446NIDA NIH HHS R01 DA051191NIDA NIH HHS R56 DA015446
6 · The paper itself

Abstract

The use of opioid drugs and related overdose deaths, which rose to epidemic proportions over the past decade, have been exacerbated by the COVID pandemic, a time of great uncertainty and isolation. Much is known about opioid pharmacology and related neural circuits that, combined with novel emerging neurobiological insights, can help guide new treatment strategies. To view this SnapShot, open or download the PDF.

Indexed as

NeurobiologyHumansNerve NetNeuronsOpioid-Related Disorders

Identifiers

PMID33740456
PMCPMC8445590

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.