Evidence map›Paper›PMID 33740423›Full record

ArticleJournal of theoretical biology2021

Dynamics of adrenergic signaling in cardiac myocytes and implications for pharmacological treatment.

Emily E Meyer, Colleen E Clancy, Timothy J Lewis

Open access · hybridAbstract read
In one paragraph

Article in Journal of theoretical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Transcriptome Profiling of Etridiazole-Exposed Zebrafish (International journal of molecular sciences · 2023
    Article
  4. Article
  5. Status of βReviews in cardiovascular medicine · 2023
    Review
  6. Role of G-Proteins and GPCRs in Cardiovascular Pathologies.Bioengineering (Basel, Switzerland) · 2023
    Review
  7. Article
  8. AKT-mTOR signaling-mediated rescue ofCardiovascular diagnosis and therapy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emily E MeyerUniversity of California Davis, Davis, CA, United States. Electronic address: eemeyer@ucdavis.edu.
Colleen E ClancyUniversity of California Davis, Davis, CA, United States.
Timothy J LewisUniversity of California Davis, Davis, CA, United States.
University of California, Davis · US

Funding

Development of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7M
In silico Safety PharmacologyR01HL128537 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2016 to 2024
$5.7M
Multi-Scale Modeling of Vascular Signaling UnitsR01HL152681 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2020 to 2023
$2.4M
NHLBI NIH HHS R01 HL128537NHLBI NIH HHS R01 HL152681NIH HHS OT2 OD026580
6 · The paper itself

Abstract

Dense innervation of the heart by the sympathetic nervous system (SNS) allows cardiac output to respond appropriately to the needs of the body under varying conditions, but occasionally the abrupt onset of SNS activity can trigger cardiac arrhythmias. Sympathetic activity leads to the release of norepinephrine (NE) onto cardiomyocytes, activating β

Indexed as

Adrenergic AgentsMyocytes, CardiacCyclic AMPHumansReceptors, Adrenergic, beta-1Signal TransductionAdrenergic AgentsCyclic AMPReceptors, Adrenergic, beta-1-blockersCyclic AMPHeart failureMathematical modelSympathetic nervous system

Identifiers

PMID33740423
PMCPMC8650805
OpenAlexW3136654197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.