Evidence map›Paper›PMID 33740380›Full record

ArticleACS chemical biology2021

Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration.

Colleen R Eade, Timothy W Wallen, Claire E Gates, Cassidy L Oliverio, Beth A Scarbrough, Amanda J Reid, Matthew A Jorgenson, Kevin D Young, Jerry M Troutman

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Colleen R EadeDepartment of Chemistry, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.
Timothy W WallenDepartment of Chemistry, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.
Claire E GatesDepartment of Chemistry, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.
Cassidy L OliverioDepartment of Chemistry, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.
Beth A ScarbroughDepartment of Chemistry, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.
Amanda J ReidDepartment of Chemistry, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.
Matthew A JorgensonDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
Kevin D YoungDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
Jerry M TroutmanDepartment of Chemistry, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.ORCID 0000-0002-8340-462X
University of North Carolina at Charlotte · USUniversity of Arkansas for Medical Sciences · US

Funding

Glycan Expression Analysis using an Odyssey CLx Infrared Imaging SystemR01GM061019 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI VOTH, DANIEL E · 2000 to 2021
$8.0M
In vitro and Cellular Tools for Complex Polysaccharide BiosynthesisR01GM123251 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI TROUTMAN, JERRY M · 2017 to 2023
$2.1M
Chemoenzymatic preparation of tagged bactoprenyl diphosphate linked sugar probes for in vitro and cellular elucidation of complex bacterial polysaccharidesF31GM130065 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI REID, AMANDA · 2018 to 2020
$101k
NIGMS NIH HHS F31 GM130065NIGMS NIH HHS R01 GM061019NIGMS NIH HHS R01 GM123251
6 · The paper itself

Abstract

The enterobacterial common antigen (ECA), a three-sugar repeat unit polysaccharide produced by Enterobacteriaceae family members, impacts bacterial outer membrane permeability, and its biosynthesis affects the glycan landscape of the organism. ECA synthesis impacts the production of other polysaccharides by reducing the availability of shared substrates, the most notable of which is the 55-carbon polyisoprenoid bactoprenyl phosphate (BP), which serves as a carrier for the production of numerous bacterial glycans including ECA, peptidoglycan, O-antigen, and more. Here, using a combination of

Indexed as

Antigens, BacterialChromatography, LiquidMass SpectrometryPolysaccharidesSubstrate SpecificityAntigens, Bacterialenterobacterial common antigenPolysaccharides

Identifiers

PMID33740380
PMCPMC8080848
OpenAlexW3138062116

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.