Evidence map›Paper›PMID 33740206›Full record

ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2021

Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness : Consensus statement of the European Federation of Autonomic Societies (EFAS) endorsed by the American Autonomic Society (AAS) and the European Academy of Neurology (EAN).

Roland D Thijs, Michele Brignole, Cristian Falup-Pecurariu, Alessandra Fanciulli, Roy Freeman, Pietro Guaraldi, Jens Jordan, Mario Habek, Max Hilz, Anne Pavy-Le Traon and 5 more

Abstract readReviewConsensus Statement
In one paragraph

Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Guideline
  3. Comparison of pain-provoked versus standard 40-min tilt table test for the conformation of vasovagal syncope.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Trial
  4. Beyond blood pressure fall: a mechanistic framework for symptom generation in orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  5. Review
  6. Article
  7. Orthostatic hypotension and complaints: not a clear-cut relation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  8. Review
  9. Article
  10. Setting up an autonomic unit within the neurological department: a position statement of the European Federation of Autonomic Societies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Autonomic nervous system abnormalities in children with inflammatory bowel disease and irritable bowel syndrome: a comparative study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Roland D ThijsDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands. r.d.thijs@lumc.nl.ORCID 0000-0003-1435-8970
Michele BrignoleFaint and Fall Programme, Department of Cardiology, Ospedale San Luca, IRCCS Istituto Auxologico Italiano, Milan, Italy.ORCID 0000-0002-1845-5607
Cristian Falup-PecurariuDepartment of Neurology, County Emergency Clinic Hospital, Transilvania University, Brasov, Romania.ORCID 0000-0002-7394-7161
Alessandra FanciulliDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-2854-4179
Roy FreemanBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3976-6022
Pietro GuaraldiIRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy.ORCID 0000-0003-0597-603X
Jens JordanGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.ORCID 0000-0003-4518-0706
Mario HabekReferral Center for Autonomic Nervous System, Department of Neurology, School of Medicine, University Hospital Center Zagreb, University of Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia.ORCID 0000-0002-3360-1748
Max HilzDepartment of Neurology, University Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000-0002-6802-1751
Anne Pavy-Le TraonNeurology Department, French Reference Center for MSA, University Hospital of Toulouse and INSERM U 1048, Toulouse, France.ORCID 0000-0002-9375-1553
Iva StankovicClinical Center of Serbia, Neurology Clinic, University of Belgrade, Belgrade, Serbia.
Walter StruhalDepartment of Neurology, University Clinic Tulln, Karl Landsteiner University of Health Sciences, Tulln, Austria.ORCID 0000-0001-7360-7784
Richard SuttonDepartment of Cardiology, National Heart and Lung Institute, Hammersmith Hospital, Ducane Road, London, W12 0NN, UK.
Gregor WenningDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
J Gert Van DijkDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0002-6953-7573

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An expert committee was formed to reach consensus on the use of tilt table testing (TTT) in the diagnosis of disorders that may cause transient loss of consciousness (TLOC) and to outline when other provocative cardiovascular autonomic tests are needed. While TTT adds to history taking, it cannot be a substitute for it. An abnormal TTT result is most meaningful if the provoked event is recognised by patients or eyewitnesses as similar to spontaneous events. The minimum requirements to perform TTT are a tilt table, a continuous beat-to-beat blood pressure monitor, at least one ECG lead, protocols for the indications stated below and trained staff. This basic equipment lends itself to the performance of (1) additional provocation tests, such as the active standing test, carotid sinus massage and autonomic function tests; (2) additional measurements, such as video, EEG, transcranial Doppler, NIRS, end-tidal CO

Indexed as

Hypotension, OrthostaticNeurologyPostural Orthostatic Tachycardia SyndromeConsensusHumansTilt-Table TestUnconsciousnessUnited StatesOrthostatic hypotensionPsychogenic pseudosyncopeReflex syncopeSyncopeTilt table testingTransient loss of consciousnessVasovagal

Identifiers

PMID33740206
PMCPMC8184725

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.