Evidence map›Paper›PMID 33740165›Full record

ArticleJournal of neuro-oncology2021

Predicting response to radiotherapy of intracranial metastases with hyperpolarized

Casey Y Lee, Hany Soliman, Nadia D Bragagnolo, Arjun Sahgal, Benjamin J Geraghty, Albert P Chen, Ruby Endre, William J Perks, Jay S Detsky, Eric Leung and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. A Static Phantom for Harmonization of Hyperpolarized [1-Magnetic resonance in medicine · 2026
    Article
  3. HyperpolarizedImaging neuroscience (Cambridge, Mass.) · 2026
    Article
  4. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  5. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  6. Review
  7. Review
  8. Hyperpolarized Carbon-13 MRI in Breast Cancer.Diagnostics (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Initial Experience on Hyperpolarized [1-Tomography (Ann Arbor, Mich.) · 2022
    Article
  13. Review
  14. HyperpolarizedNeuro-oncology advances
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Casey Y LeeDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Hany SolimanRadiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Nadia D BragagnoloDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Arjun SahgalRadiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Benjamin J GeraghtyPhysical Sciences, Sunnybrook Research Institute, M7-613, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
Albert P ChenGE Healthcare, Toronto, Ontario, Canada.
Ruby EndrePhysical Sciences, Sunnybrook Research Institute, M7-613, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
William J PerksPharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Jay S DetskyRadiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Eric LeungRadiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Michael ChanRadiology, Trillium Health Partners, Mississauga, ON, Canada.
Chris HeynRadiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Charles H CunninghamDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada. charles.cunningham@utoronto.ca.ORCID 0000-0001-9636-8130
Sunnybrook Health Science Centre · CATrillium Health Centre · CA

Funding

CIHR PJT152928
6 · The paper itself

Abstract

backgroundStereotactic radiosurgery (SRS) is used to manage intracranial metastases in a significant fraction of patients. Local progression after SRS can often only be detected with increased volume of enhancement on serial MRI scans which may lag true progression by weeks or months.

methodsPatients with intracranial metastases (N = 11) were scanned using hyperpolarized

resultsThe positive predictive value of

conclusionsHyperpolarized

Indexed as

Brain NeoplasmsRadiosurgeryHumansLactatesMagnetic Resonance ImagingRetrospective StudiesLactatesHyperpolarized 13C MRIIntracranial metastasesLactateMetabolismSRS

Identifiers

PMID33740165
PMCPMC8084843
OpenAlexW3138392633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.