Evidence map›Paper›PMID 33740097›Full record

ArticleVirchows Archiv : an international journal of pathology2021

Cardiac hypertrophy at autopsy.

Cristina Basso, Katarzyna Michaud, Giulia d'Amati, Jytte Banner, Joaquin Lucena, Kristopher Cunningham, Ornella Leone, Aryan Vink, Allard C van der Wal, Mary N Sheppard and 1 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  10. Countywide burden, pathology, and genetics of lethal hypertrophic cardiomyopathy: from the POST SCD study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  11. ANMCO position paper 'Hypertrophic cardiomyopathy: from diagnosis to treatment'.European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
  12. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 7 countries.

Cristina BassoCardiovascular Pathology Unit, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy. cristina.basso@unipd.it.ORCID http://orcid.org/0000-0002-0195-9753
Katarzyna MichaudUniversity Center of Legal Medicine Lausanne - Geneva, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Giulia d'AmatiDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Jytte BannerDepartment of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark.
Joaquin LucenaForensic Pathology Service, Institute of Legal Medicine and Forensic Sciences, Seville, Spain.
Kristopher CunninghamDepartment of Laboratory Medicine and Pathobiology, Ontario Forensic Pathology Service, University of Toronto, Toronto, Canada.
Ornella LeoneCardiovascular and Cardiac Transplant Pathology Unit, Department of Pathology, Sant'Orsola-Malpighi University Hospital, Bologna, Italy.
Aryan VinkUniversity Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Allard C van der WalAmsterdam UMC, Academic Medical Center, Amsterdam, The Netherlands.
Mary N SheppardDepartment of Cardiovascular Pathology, Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Institute, St George's Medical School, London, UK.
Association for European Cardiovascular Pathology
Amsterdam UMC Location University of Amsterdam · NLInstituto Nacional de Toxicología y Ciencias Forenses · ESIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITSapienza University of Rome · ITSt George's, University of London · GBUniversity Centre of Legal Medicine · CHUniversity of Copenhagen · DKUniversity of Padua · ITUniversity of Toronto · CAUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since cardiac hypertrophy may be considered a cause of death at autopsy, its assessment requires a uniform approach. Common terminology and methodology to measure the heart weight, size, and thickness as well as a systematic use of cut off values for normality by age, gender, and body weight and height are needed. For these reasons, recommendations have been written on behalf of the Association for European Cardiovascular Pathology. The diagnostic work up implies the search for pressure and volume overload conditions, compensatory hypertrophy, storage and infiltrative disorders, and cardiomyopathies. Although some gross morphologic features can point to a specific diagnosis, systematic histologic analysis, followed by possible immunostaining and transmission electron microscopy, is essential for a final diagnosis. If the autopsy is carried out in a general or forensic pathology service without expertise in cardiovascular pathology, the entire heart (or pictures) together with mapped histologic slides should be sent for a second opinion to a pathologist with such an expertise. Indication for postmortem genetic testing should be integrated into the multidisciplinary management of sudden cardiac death.

Indexed as

AutopsyCardiomegalyCause of DeathGenetic TestingHumansMyocardiumOrgan SizePredictive Value of TestsRisk FactorsTerminology as TopicAutopsyCardiovascular diseasesDiagnostic criteriaHypertrophyQuality in pathology

Identifiers

PMID33740097
PMCPMC8298245
OpenAlexW3136695492

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.