Evidence map›Paper›PMID 33740060›Full record

ArticleThe American journal of clinical nutrition2021

Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.

Konstantinos K Tsilidis, Nikos Papadimitriou, Niki Dimou, Dipender Gill, Sarah J Lewis, Richard M Martin, Neil Murphy, Georgios Markozannes, Verena Zuber, Amanda J Cross and 78 more

Erratum issued Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02328677 recruitingnot on this map

ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis

TypeobservationalSponsorUniversity of UtahRan2007 to 2030Enrolled5,000ConditionsColorectal Cancer
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  9. A two-sample Mendelian randomization study of mutual relations of six types of diets in atopic dermatitis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  10. Review
  11. Review
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  14. Scientific opinion on the tolerable upper intake level for folate.EFSA journal. European Food Safety Authority · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

88 authors at 20 institutions in 17 countries.

Konstantinos K TsilidisDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
Nikos PapadimitriouSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Niki DimouSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Dipender GillDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.ORCID 0000-0001-7312-7078
Sarah J LewisDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Richard M MartinDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Neil MurphySection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Georgios MarkozannesDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
Verena ZuberDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.ORCID 0000-0001-9827-1877
Amanda J CrossDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Kimberley BurrowsDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
David S LopezDepartment of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0002-2321-0372
Timothy J KeyNuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Ruth C TravisNuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Aurora Perez-CornagoNuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-5652-356X
David J HunterNuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Fränzel J B van DuijnhovenDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-8330-4293
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9320-8684
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Stéphane BézieauMedical Genetics Service, University Hospital Center (CHU) Nantes, Nantes, France.
D Timothy Bishop, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom.ORCID 0000-0002-8752-8785
Juergen BoehmHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Andrea Burnett-HartmanInstitute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA.
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.ORCID 0000-0002-5549-2036
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Sergi Castellví-BelGastroenterology Department, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Biomedical Research Network Center for Liver and Digestive Diseases (CIBEREHD), University of Barcelona, Barcelona, Spain.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Albert de la ChapelleDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.
Jane C FigueiredoDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Steven J GallingerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Andrea GsurInstitute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria.ORCID 0000-0002-9795-1528
Jochen HampeDepartment of Medicine I, University Hospital Dresden, Dresden University of Technology (TU Dresden), Dresden, Germany.
Heather HampelDivision of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8307-3197
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Temitope O KekuCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Sun-Seog KweonDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Susanna C LarssonInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0003-0118-0341
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Christopher I LiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Li LiDepartment of Family Medicine, University of Virginia, Charlottesville, VA, USA.
Annika LindblomDepartment of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Vicente MartínCIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0001-5764-7268
Victor MorenoCIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.ORCID 0000-0002-2818-5487
Hongmei NanDepartment of Epidemiology, Richard M Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
Rami NassirDepartment of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia.
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kenneth OffitClinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Paul D P PharoahDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Lihong QiDepartment of Public Health Sciences, School of Medicine, University of California Davis, Davis, CA, USA.
Gad RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.ORCID 0000-0002-8512-068X
Lori C SakodaPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0002-0900-5735
Clemens SchafmayerDepartment of General Surgery, University Hospital Rostock, Rostock, Germany.
Martha L SlatteryDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Linda SnetselaarDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA.
Jeanette SchenkSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Stephen N ThibodeauDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Cornelia M UlrichHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.ORCID 0000-0002-9692-101X
Sophia HarlidDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-0582-8005
Ludmila VodickovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Hansong WangUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Michael O WoodsDiscipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0003-1226-070X
Bas Bueno-de-MesquitaFormerly, Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Marie-Christine Boutron-RuaultFaculty of Medicine, CESP, University of Paris-Sud, Faculty of Medicine UVSQ, INSERM, University of Paris-Saclay, Villejuif, France.ORCID 0000-0002-5956-5693
David J HughesCancer Biology and Therapeutics Group, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Paula JakszynUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology- Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.ORCID 0000-0001-6795-6080
Edward L GiovannucciChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Barbara L BanburyPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Stephen B GruberDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Marc J GunterSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0001-5472-6761
Broad Institute · USCentre international de recherche sur le cancer · FRGerman Cancer Research Center · DEUniversity of Ioannina · GRUniversity of Oxford · GBImperial College London · GBNational Cancer Institute · USNational Health Service · GBUniversity of Bristol · GBAmerican Cancer Society · USBrigham and Women's Hospital · USCentre Hospitalier Universitaire de Nantes · FRCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESKaiser Permanente · USThe University of Melbourne · AUThe University of Texas Medical Branch at Galveston · USUniversität Hamburg · DEUniversité Paris-Sud · FRUniversity College Dublin · IEUniversity of Cambridge · GB

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Transdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6M
Data sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8M
PCPT and SELECT Cohorts: Core Infrastructure Support for Cancer ResearchU01CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2019 to 2023
$5.4M
PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research UM1CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2013 to 2017
$5.2M
Metabolomic Strategies for Discovery and Validation of Biomarkers of Colorectal Cancer RecurrenceR01CA207371 · NCI · UNIVERSITY OF UTAH · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2017 to 2022
$3.9M
Advancing equity in colorectal cancer genetic risk prediction through expansion of racial/ethnic minority representationR01CA244588 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2020 to 2024
$3.5M
Cancer Research UK 16561Cancer Research UK 19167Cancer Research UK 19169Cancer Research UK 25004Cancer Research UK 29019Cancer Research UK 29186Cancer Research UK C18281/A19169Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013/3NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA207371NCI NIH HHS R01 CA244588NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA182883NCI NIH HHS U01 CA206110NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA182883NIEHS NIH HHS P30 ES010126World Health Organization 001
6 · The paper itself

Abstract

backgroundThe literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited.

objectivesTo complement observational and RCT findings, we investigated associations of genetically predicted concentrations of 11 micronutrients (β-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc) with colorectal cancer risk using Mendelian randomization (MR).

methodsTwo-sample MR was conducted using 58,221 individuals with colorectal cancer and 67,694 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Inverse variance-weighted MR analyses were performed with sensitivity analyses to assess the impact of potential violations of MR assumptions.

resultsNominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ORs per SD (ORSD): 1.08; 95% CI: 1.00, 1.17; P value = 0.05] and similarly for proximal colon cancer, and for vitamin B-12 concentration and higher risk of colorectal cancer (ORSD: 1.12; 95% CI: 1.03, 1.21; P value = 0.01) and similarly for colon cancer. A nominally significant association was also noted for genetically predicted selenium concentration and lower risk of colon cancer (ORSD: 0.98; 95% CI: 0.96, 1.00; P value = 0.05) and similarly for distal colon cancer. These associations were robust to sensitivity analyses. Nominally significant inverse associations were observed for zinc and risk of colorectal and distal colon cancers, but sensitivity analyses could not be performed. None of these findings survived correction for multiple testing. Genetically predicted concentrations of β-carotene, calcium, copper, folate, magnesium, phosphorus, and vitamin B-6 were not associated with disease risk.

conclusionsThese results suggest possible causal associations of circulating iron and vitamin B-12 (positively) and selenium (inversely) with risk of colon cancer.

Indexed as

Genetic Predisposition to DiseaseMendelian Randomization AnalysisWhite PeopleCase-Control StudiesColorectal NeoplasmsDietary SupplementsHumansMicronutrientsRisk FactorsSeleniumVitamin B 12MicronutrientsSeleniumVitamin B 12colorectal cancergenesMendelian randomizationnutritionsupplements

Identifiers

PMID33740060
PMCPMC8168352
OpenAlexW3119508678

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.