ArticlePLoS pathogens2021
Resident bacteria contribute to opportunistic infections of the respiratory tract.
Article in PLoS pathogens, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the chicken respiratory microbiome: a comprehensive meta-analysis of factors shaping chicken respiratory microbiota.Scientific reports · 2026Pooled it
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- A Two-Year Study on Swifts (Pathogens (Basel, Switzerland) · 2026Article
- Research progress onFrontiers in microbiology · 2026Review
- Effects of Gallic Acid Supplementation on Intestinal Function and Gut Microbial Community Structure inAquaculture nutrition · 2026Article
- Development of selective culture media for efficient isolation ofJournal of clinical microbiology · 2025Article
- Natural Microbiota of Dogs and Cats as a Source and Vector of Resistance Genes-Clinical Significance.International journal of molecular sciences · 2025Review
- Article
- Dielectrophoresis for Isolating Low-Abundance Bacteria Obscured by Impurities in Environmental Samples.Marine biotechnology (New York, N.Y.) · 2025Article
- Accurate Diagnosis of Lower Respiratory Infections Using Host Response and Respiratory Microbiome from a Single Metatranscriptome Test of Bronchoalveolar Lavage Fluid.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Deep longitudinal lower respiratory tract microbiome profiling reveals genome-resolved functional and evolutionary dynamics in critical illness.Nature communications · 2024Article
- A detailed analysis of 16S rRNA gene sequencing and conventional PCR-based testing for the diagnosis of bacterial pathogens and discovery of novel bacteria.Antonie van Leeuwenhoek · 2024Article
- Antibacterial potential of Propolis: molecular docking, simulation and toxicity analysis.AMB Express · 2024Article
- Exploring the complexities of poultry respiratory microbiota: colonization, composition, and impact on health.Animal microbiome · 2024Review
- Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages.Journal of advanced research · 2024Article
- Coumarin Glycosides Reverse Enterococci-Facilitated Enteric Infections.Research (Washington, D.C.) · 2024Article
- Development and Validation of PCR Diagnostic Assays for Detection ofVeterinary sciences · 2023Article
- Article
- Development of an environmental contamination model to simulate the microbial bloom that occurs in commercial hatch cabinets.Poultry science · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opportunistic pathogens frequently cause volatile infections in hosts with compromised immune systems or a disrupted normal microbiota. The commensalism of diverse microorganisms contributes to colonization resistance, which prevents the expansion of opportunistic pathogens. Following microbiota disruption, pathogens promptly adapt to altered niches and obtain growth advantages. Nevertheless, whether and how resident bacteria modulate the growth dynamics of invasive pathogens and the eventual outcome of such infections are still unclear. Here, we utilized birds as a model animal and observed a resident bacterium exacerbating the invasion of Avibacterium paragallinarum (previously Haemophilus paragallinarum) in the respiratory tract. We first found that negligibly abundant Staphylococcus chromogenes, rather than Staphylococcus aureus, played a dominant role in Av. paragallinarum-associated infectious coryza in poultry based on epidemic investigations and in vitro analyses. Furthermore, we determined that S. chromogenes not only directly provides the necessary nutrition factor nicotinamide adenine dinucleotide (NAD+) but also accelerates its biosynthesis and release from host cells to promote the survival and growth of Av. paragallinarum. Last, we successfully intervened in Av. paragallinarum-associated infections in animal models using antibiotics that specifically target S. chromogenes. Our findings show that opportunistic pathogens can hijack commensal bacteria to initiate infection and expansion and suggest a new paradigm to ameliorate opportunistic infections by modulating the dynamics of resident bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.