Evidence map›Paper›PMID 33739997›Full record

ArticlePloS one2021

Quantitative assessment of retinal thickness and vessel density using optical coherence tomography angiography in patients with Alzheimer's disease and glaucoma.

Przemyslaw Zabel, Jakub J Kaluzny, Katarzyna Zabel, Martyna Kaluzna, Aleksander Lamkowski, Damian Jaworski, Jaroslaw Makowski, Martyna Gebska-Toloczko, Robert Kucharski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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  9. Identification of Alzheimer's Disease by Imaging: A Comprehensive Review.International journal of environmental research and public health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Przemyslaw ZabelDepartment of Sensory Organ Studies, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.ORCID 0000-0002-5219-9811
Jakub J KaluznyDepartment of Sensory Organ Studies, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.
Katarzyna ZabelDepartment of Sensory Organ Studies, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.
Martyna KaluznaOftalmika Eye Hospital, Bydgoszcz, Poland.
Aleksander LamkowskiOftalmika Eye Hospital, Bydgoszcz, Poland.
Damian JaworskiOftalmika Eye Hospital, Bydgoszcz, Poland.
Jaroslaw MakowskiOftalmika Eye Hospital, Bydgoszcz, Poland.
Martyna Gebska-ToloczkoDepartment of Sensory Organ Studies, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.
Robert KucharskiCenter of Psychoneurology in Elderly, Sue Ryder Home leading by Pallmed Ltd, Bydgoszcz, Poland.
Nicolaus Copernicus University · PLUniversity of Bydgoszcz · PLNZOZ Dom Sue Ryder · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAssessment and a direct comparison of retinal vessel density with the thickness of inner retinal layer (IRL) and outer retinal layer (ORL) in the same regions of the macula in subjects with Alzheimer's disease (AD) and primary open-angle glaucoma (POAG).

methodsWe analyzed data from 48 eyes of healthy control (HC) participants, 71 eyes with POAG, and 49 eyes of AD patients. Ophthalmic examination included optical coherence tomography (OCT) imaging to measure IRL and ORL thickness and OCT angiography (OCTA) in the same region for the imaging of vessel density in the superficial vascular plexus (SVP) and deep vascular plexus (DVP) of the retina. A direct comparison of vessel density and retinal layers thickness, which different dynamic ranges, was obtained by normalizing values as percentage losses.

resultsPatients with AD presented significantly greater losses of vascular density in the DVP and ORL thickness compared to POAG (p <0.001), but percentage losses of vessel density in SVP and IRL thickness were considerable in POAG compared to AD eyes (p<0.001). Positive associations among presence of AD were observed primarily in outer retina where a 1% decrease of ORL thickness was associated with about 24-29% increase in odds of the presence of AD. According to OCTA measurements, a 1% decrease of vessel density in DVP was positively associated with a 4-9% increase in odds of the presence of AD. In POAG positive associations among presence of disease were observed only in inner retina where 1% loss of IRL thickness and a 1% loss of vessel density in the SVP were positively associated with a 13-23% increase in risk of presence of the disease.

conclusionsAnalysis of ORL thickness and vessel density in DVP could potentially improve diagnostic capabilities and may provide a valuable approach for predicting of AD.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesFemaleGlaucoma, Open-AngleHumansMacula LuteaMaleOptic DiskPolandRetinal Vessels

Identifiers

PMID33739997
PMCPMC7978346
OpenAlexW3112567963

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.