ArticlePLoS neglected tropical diseases2021
Soil-transmitted helminth infection in pregnancy and long-term child neurocognitive and behavioral development: A prospective mother-child cohort in Benin.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Parasitic Infections and Associated Cognitive Outcome Among School-Aged Children in Africa: A Systematic Review.Brain and behavior · 2026Pooled it
- Prevalence and correlates of soil-transmitted helminths in schoolchildren aged 5 to 18 years in low- and middle-income countries: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Prevalence of Malaria and Soil-Transmitted Helminths and Associated Factors Among Pregnant Women Visiting Mizan-Tepi University Teaching Hospital, Southwest Ethiopia.Journal of parasitology research · 2026Article
- Geohelminthiasis and Malaria Co-Infection in Pregnant Women in Kinshasa: Case of Lisungi and Lukunga Hospitals in Democratic Republic of the Congo.Pathogens (Basel, Switzerland) · 2025Article
- Geophagy as a risk factor for Soil-transmitted helminthic infections among pregnant women attending antenatal care at health institutions in Chiro Town, Eastern Ethiopia.BMC pregnancy and childbirth · 2025Observational
- Optimizing community health workers and nonbiomedical approaches to assess the burden of soil-transmitted helminthiasis in a school-aged population in rural Rwanda.BMC primary care · 2025Article
- Determinants of uptake of deworming medication during pregnancy in Tanzania: insights from 2022 demographic and health survey.Journal of health, population, and nutrition · 2025Article
- Prenatal Hemoglobin Concentration and Long-Term Child Neurocognitive Development.The American journal of tropical medicine and hygiene · 2025Article
- Associations between the Strengths and Difficulties Questionnaire (SDQ) and Tests of Variables of Attention (TOVA) in rural school-aged children in Benin Africa.Global mental health (Cambridge, England) · 2025Article
- Helminthiasis in school-age children from Gresik, East Java, Indonesia.Helminthologia · 2024Article
- Community-based prevalence, intensity and risk factors associated with soil-transmitted helminthiases and intestinal schistosomiasis in Apojola, Ogun state, southwest Nigeria.BMC infectious diseases · 2024Article
- Soil-transmitted helminths: A critical review of the impact of co-infections and implications for control and elimination.PLoS neglected tropical diseases · 2023Review
- Soil-Transmitted Helminth Infections among Antenatal Women in Primary Care Settings in Southern India: Prevalence, Associated Factors and Effect of Anti-Helminthic Treatment.Tropical medicine and infectious disease · 2023Article
- Deworming utilization among pregnant mothers with at least one antenatal care follow-up in Ethiopia, 2022:- A multilevel analysis.PloS one · 2023Article
- Three-Dimensional Models of Soil-Transmitted Helminth Eggs from Light Microscopy Images.Tropical medicine and infectious disease · 2022Article
- The burden of soil-transmitted helminths infections among pregnant women in Maharashtra and Rajasthan states of India.Journal of family medicine and primary care · 2022Article
- Neurocognitive outcomes in Malawian children exposed to malaria during pregnancy: An observational birth cohort study.PLoS medicine · 2021Observational
- Neurodevelopmental assessment at one year of age predicts neuropsychological performance at six years in a cohort of West African Children.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021Article
- Diagnostic Techniques for Soil-Transmitted Helminths - Recent Advances.Research and reports in tropical medicine · 2021Review
- Estimation of the Parasitic Burden of Soil-Transmitted Helminths Among Pregnant Women in the Maharashtra State of India Using qPCR: A Community-Based Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
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10 authors at 7 institutions in 4 countries.
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Abstract
backgroundAn estimated 30% of women in Sub-Saharan Africa suffer from soil-transmitted helminth infection during pregnancy (SHIP), which has been shown to increase risk of pre-term birth, low birth weight, and maternal anemia. A previous study in Benin found that SHIP was associated with impaired cognitive and gross motor development scores in 635 one-year-old children. The objective of the present study was to follow children prospectively to investigate whether the association between SHIP and child neurocognitive and behavioral development persisted at age six. PRINCIPAL
findingsOur prospective child cohort included 487 live-born singletons of pregnant women enrolled in the Malaria in Pregnancy Preventive Alternative Drugs clinical trial in Allada, Benin. SHIP was assessed at three antenatal visits (ANVs) through collection and testing of stool samples. Neurocognitive and behavioral development was assessed in six-year-old children by trained investigators using the Kaufman Assessment Battery for Children 2nd edition and the parent-reported Strengths and Difficulties Questionnaire (SDQ). Multiple linear regression models generated coefficients and 95% confidence intervals and potential mediating factors were tested. Prevalence of SHIP was 13% at the 1st ANV, 9% at the 2nd ANV, and 1% at delivery. SHIP was not associated with low neurocognitive scores in children at six years. Higher SDQ internalizing scores, indicating increased emotional impairments in children, were associated with helminth infection at the 2nd ANV/delivery 1.07 (95% CI 0.15, 2.00) and at least once during pregnancy 0.79 (95% CI 0.12, 1.46) in adjusted models. Mediation analysis did not reveal significant indirect effects of several mediators on this association.
conclusionsOur study shows that while SHIP is not associated with impaired long-term neurocognitive development, infections may have significant negative impacts on emotional development in six-year-old children. SHIP remains a critical public health issue, and adequate prevention and treatment protocols should be enforced in low- and middle-income countries.
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