Evidence map›Paper›PMID 33739823›Full record

ArticleACS infectious diseases2021

Cationic Homopolymers Inhibit Spore and Vegetative Cell Growth of

Joshua B Jones, Lei Liu, Leslie A Rank, Daniela Wetzel, Emily C Woods, Naomi Biok, Sarah E Anderson, Myung-Ryul Lee, Runhui Liu, Sean Huth and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Joshua B JonesDepartment of Microbiology and Immunology, Emory University School of Medicine, Emory Antibiotic Resistance Center, Atlanta, Georgia 30322, United States.
Lei LiuDepartment of Chemistry and Department of Medicine, University of Wisconsin, Madison, Wisconsin 53706, United States.ORCID 0000-0001-7782-4559
Leslie A RankJohnson & Johnson Inc., Skillman, New Jersey 08558, United States.ORCID 0000-0001-9551-5004
Daniela WetzelDepartment of Microbiology and Immunology, Emory University School of Medicine, Emory Antibiotic Resistance Center, Atlanta, Georgia 30322, United States.
Emily C WoodsDepartment of Medicine, Stanford University School of Medicine, Stanford, California 94305-5119, United States.
Naomi BiokDepartment of Chemistry and Department of Medicine, University of Wisconsin, Madison, Wisconsin 53706, United States.
Sarah E AndersonDepartment of Biology, Washington University, St. Louis, Missouri 63130-4899, United States.
Myung-Ryul LeeDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801-3028, United States.
Runhui LiuState Key Laboratory of Bioreactor Engineering, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.ORCID 0000-0002-7699-086X
Sean HuthDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544-1009, United States.ORCID 0000-0002-4892-2587
Brindar K SandhuDepartment of Microbiology and Immunology, Emory University School of Medicine, Emory Antibiotic Resistance Center, Atlanta, Georgia 30322, United States.
Samuel H GellmanDepartment of Chemistry and Department of Medicine, University of Wisconsin, Madison, Wisconsin 53706, United States.ORCID 0000-0001-5617-0058
Shonna M McBrideDepartment of Microbiology and Immunology, Emory University School of Medicine, Emory Antibiotic Resistance Center, Atlanta, Georgia 30322, United States.ORCID 0000-0001-6221-714X
Emory University · USUniversity of Wisconsin–Madison · USEast China University of Science and Technology · CNJohnson & Johnson (United States) · USPrinceton University · USStanford University · USUniversity of Illinois Urbana-Champaign · USWashington University in St. Louis · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
Host-induced Initiation of Clostridium difficile SporulationR01AI116933 · NIAID · EMORY UNIVERSITY · PI SHONNA M. MCBRIDE · 2015 to 2026
$4.8M
Antimicrobial Resistance and Therapeutic Discovery Training ProgramT32AI106699 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Joanna B Goldberg · 2014 to 2026
$2.7M
Polymeric Agents for the Treatment of Clostridium difficile InfectionsR33AI121684 · NIAID · EMORY UNIVERSITY · PI GELLMAN, SAMUEL H., MCBRIDE, SHONNA M. · 2018 to 2020
$1.4M
NIAID NIH HHS R01 AI116933NIAID NIH HHS R33 AI121684NIAID NIH HHS T32 AI106699NIGMS NIH HHS T32 GM008169NIGMS NIH HHS T32 GM008490
6 · The paper itself

Abstract

A wide range of synthetic polymers have been explored for antimicrobial activity. These materials usually contain both cationic and hydrophobic subunits because these two characteristics are prominent among host-defense peptides. Here, we describe a series of nylon-3 polymers containing only cationic subunits and their evaluation against the gastrointestinal, spore-forming pathogen

Indexed as

Clostridioides difficileAnti-Bacterial AgentsCell WallClostridioidesHumansSpores, BacterialAnti-Bacterial AgentscationicClostridioides difficileClostridium difficilehomopolymerspoly-β-peptidestherapeutics

Identifiers

PMID33739823
PMCPMC8130196
OpenAlexW3137415668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.