Evidence map›Paper›PMID 33739800›Full record

ArticleJBRA assisted reproduction2021

Association of FSHR, LH, LHR, BMP15, GDF9, AMH, and AMHR polymorphisms with poor ovarian response in patients undergoing in vitro fertilization.

Arivaldo José Conceição Meireles, João Paolo Bilibio, Pânila Longhi Lorenzzoni, Emily De Conto, Fábio Costa do Nascimento, João Sabino da Cunha-Filho

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBRA assisted reproduction, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Significance ofInternational journal of reproductive biomedicine · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Arivaldo José Conceição MeirelesClinica Pronatus Centro de Reprodução Humana, Belém, Pará, Brazil.
João Paolo BilibioClinica Pronatus Centro de Reprodução Humana, Belém, Pará, Brazil.
Pânila Longhi LorenzzoniClinica Pronatus Centro de Reprodução Humana, Belém, Pará, Brazil.
Emily De ContoPrograma de Pós Graduação de Ciências Médicas da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Fábio Costa do NascimentoClinica Pronatus Centro de Reprodução Humana, Belém, Pará, Brazil.
João Sabino da Cunha-FilhoPrograma de Pós Graduação de Ciências Médicas da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Universidade Federal do Rio Grande do Sul · BRAssociação Fundo de Incentivo à Pesquisa · BRCentro de Reprodução Humana Prof. Franco Junior · BRHospital de Clínicas de Porto Alegre · BRUniversidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis paper aimed to assess the correlation between LH, LHR, GDF9, FSHR, AMH, AMHR2, and BMP15 polymorphisms, which are related to follicular development, and decreased ovarian response in women undergoing controlled ovarian hyperstimulation (COH) for IVF.

methodsThis age-matched case-control study included three or four controls per woman undergoing COH. Controls were women with normal ovarian response (NOR) and cases were women with poor ovarian response (POR) in oocyte retrieval (three or fewer oocytes). DNA was extracted from peripheral blood and potential associations with gene polymorphisms related to follicular development (LH, LHR, GDF9, FSHR, AMH, AMHR2, and BMP15) were analyzed.

resultsSixty-six patients were included, 52 in the NOR and 14 in the POR group. Two GDF9 polymorphisms were associated with follicular response after COH, one associated with POR - the presence of a mutant polymorphism in heterozygosis and homozygosis of the GDF9 398-39 (C to G) [23% NOR versus 68% POR (OR 4.01, CI 1.52-10.6, p=0.005)] - and another associated with protective response - the presence of normal homozygosis of GDF9 (C447T) [19.2% NOR versus 50% POR (OR 0.34, IC 0.14-0.84, p=0.019)]. No additional associations were found between the other analyzed polymorphisms and POR.

conclusionsThis study found that GDF9 appears to play an important role in follicular development, whereas polymorphisms in its DNA chain may negatively affect ovarian reserve, such as 398-39 (C to G), or positively, as seen in C447T.

Indexed as

Fertilization in VitroOvarian ReserveBone Morphogenetic Protein 15Case-Control StudiesFemaleGrowth Differentiation Factor 9HumansOvaryPolymorphism, GeneticBMP15 protein, humanBone Morphogenetic Protein 15GDF9 protein, humanGrowth Differentiation Factor 9IVFovarian reservepolymorphismspoor ovarian responseSNPs

Identifiers

PMID33739800
PMCPMC8312286
OpenAlexW3137641055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.