Evidence map›Paper›PMID 33739634›Full record

ArticleKorean journal of radiology2021

Cycle-Consistent Generative Adversarial Network: Effect on Radiation Dose Reduction and Image Quality Improvement in Ultralow-Dose CT for Evaluation of Pulmonary Tuberculosis.

Chenggong Yan, Jie Lin, Haixia Li, Jun Xu, Tianjing Zhang, Hao Chen, Henry C Woodruff, Guangyao Wu, Siqi Zhang, Yikai Xu and 1 more

Abstract read
In one paragraph

Article in Korean journal of radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Revolutionizing diagnosis of pulmonaryFrontiers in microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chenggong YanDepartment of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0002-2968-4595
Jie LinDepartment of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0003-1089-4143
Haixia LiClinical and Technical Solution, Philips Healthcare, Guangzhou, China.ORCID 0000-0002-4818-4107
Jun XuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0001-7621-3617
Tianjing ZhangClinical and Technical Solution, Philips Healthcare, Guangzhou, China.ORCID 0000-0002-7809-6845
Hao ChenJiangsu JITRI Sioux Technologies Co., Ltd., Suzhou, China.ORCID 0000-0001-5887-039X
Henry C WoodruffThe D-Lab, Department of Precision Medicine, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0001-7911-5123
Guangyao WuThe D-Lab, Department of Precision Medicine, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0003-0658-2956
Siqi ZhangDepartment of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0002-1382-0708
Yikai XuDepartment of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. yikaixu917@gmail.com.ORCID 0000-0003-1607-5077
Philippe LambinThe D-Lab, Department of Precision Medicine, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0001-7961-0191

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the image quality of ultralow-dose CT (ULDCT) of the chest reconstructed using a cycle-consistent generative adversarial network (CycleGAN)-based deep learning method in the evaluation of pulmonary tuberculosis. MATERIALS AND

methodsBetween June 2019 and November 2019, 103 patients (mean age, 40.8 ± 13.6 years; 61 men and 42 women) with pulmonary tuberculosis were prospectively enrolled to undergo standard-dose CT (120 kVp with automated exposure control), followed immediately by ULDCT (80 kVp and 10 mAs). The images of the two successive scans were used to train the CycleGAN framework for image-to-image translation. The denoising efficacy of the CycleGAN algorithm was compared with that of hybrid and model-based iterative reconstruction. Repeated-measures analysis of variance and Wilcoxon signed-rank test were performed to compare the objective measurements and the subjective image quality scores, respectively.

resultsWith the optimized CycleGAN denoising model, using the ULDCT images as input, the peak signal-to-noise ratio and structural similarity index improved by 2.0 dB and 0.21, respectively. The CycleGAN-generated denoised ULDCT images typically provided satisfactory image quality for optimal visibility of anatomic structures and pathological findings, with a lower level of image noise (mean ± standard deviation [SD], 19.5 ± 3.0 Hounsfield unit [HU]) than that of the hybrid (66.3 ± 10.5 HU,

conclusionThe optimized CycleGAN technique may allow the synthesis of diagnostically acceptable images from ULDCT of the chest for the evaluation of pulmonary tuberculosis.

Indexed as

Quality ImprovementTuberculosis, PulmonaryAdultAlgorithmsDrug TaperingFemaleHumansMaleMiddle AgedRadiation DosageRadiographic Image Interpretation, Computer-AssistedSignal-To-Noise RatioTomography, X-Ray ComputedArtificial intelligenceComputed tomographyDeep learningInfectionRadiation dose

Identifiers

PMID33739634
PMCPMC8154783

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.