ArticleChembiochem : a European journal of chemical biology2021
Biosynthesis of Sinapigladioside, an Antifungal Isothiocyanate from Burkholderia Symbionts.
Article in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 24 citations in OpenAlex.
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- Isolation and Identification ofMicroorganisms · 2025Article
- The Enigma of Sponge-Derived Terpenoid Isothiocyanate-Thiocyanate Pairs: A Biosynthetic Proposal.Marine drugs · 2025Review
- Repeated horizontal acquisition of lagriamide-producing symbionts in Lagriinae beetles.bioRxiv : the preprint server for biology · 2024Article
- Actinobacterial chalkophores: the biosynthesis of hazimycins.The Journal of antibiotics · 2024Article
- Repeated horizontal acquisition of lagriamide-producing symbionts in Lagriinae beetles.The ISME journal · 2024Article
- The many facets of sulfur incorporation in natural product biosynthesis.Current opinion in chemical biology · 2023Review
- Polyyne-producingFrontiers in microbiology · 2023Article
- Article
- Biotechnology approaches for natural product discovery, engineering, and production based on Burkholderia bacteria.Current opinion in biotechnology · 2022Review
- Biosynthesis of Isonitrile- and Alkyne-Containing Natural Products.Annual review of chemical and biomolecular engineering · 2022Review
- Genome mining methods to discover bioactive natural products.Natural product reports · 2021Review
- Multimodal Molecular Imaging and Identification of Bacterial Toxins Causing Mushroom Soft Rot and Cavity Disease.Chembiochem : a European journal of chemical biology · 2021Article
- Biosynthesis of Sinapigladioside, an Antifungal Isothiocyanate from Burkholderia Symbionts.Chembiochem : a European journal of chemical biology · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Sinapigladioside is a rare isothiocyanate-bearing natural product from beetle-associated bacteria (Burkholderia gladioli) that might protect beetle offspring against entomopathogenic fungi. The biosynthetic origin of sinapigladioside has been elusive, and little is known about bacterial isothiocyanate biosynthesis in general. On the basis of stable-isotope labeling, bioinformatics, and mutagenesis, we identified the sinapigladioside biosynthesis gene cluster in the symbiont and found that an isonitrile synthase plays a key role in the biosynthetic pathway. Genome mining and network analyses indicate that related gene clusters are distributed across various bacterial phyla including producers of both nitriles and isothiocyanates. Our findings support a model for bacterial isothiocyanate biosynthesis by sulfur transfer into isonitrile precursors.
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