ArticleHuman brain mapping2021
Opposing relationships of childhood threat and deprivation with stria terminalis white matter.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Adolescents' ventral striatal reward neural activity moderates the association between lifetime trauma exposure and lower depression after 6 months.European journal of psychotraumatology · 2026Article
- Sex-specific associations of childhood adversity with frontostriatal network organization and anhedonia in young adulthood.bioRxiv : the preprint server for biology · 2026Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Hearing and early life adversity: effects of developmental stress on sensory processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Connectometry reveals differing associations of cortisol and PACAP with dorsal cingulum microstructure in posttraumatic stress.medRxiv : the preprint server for health sciences · 2025Article
- The contribution of childhood trauma to irritability symptoms.JCPP advances · 2025Article
- Trauma-Based Sexually Dimorphic Changes in the Connectome and Its Association with Central Sensitization Syndromes-A Systematic Review.Brain sciences · 2024Review
- A Preliminary Investigation of a Conceptual Model Describing the Associations Between Childhood Maltreatment and Alcohol Use Problems.Brain sciences · 2024Article
- Childhood Adversity and Adult Inflammation: Exploring the Mediating Role of Emotion Regulation in the MIDUS II Study.Journal of child & adolescent trauma · 2024Article
- The Dichotomy of Threat and Deprivation as Subtypes of Childhood Maltreatment: Differential Functional Connectivity Patterns of Threat and Reward Circuits in an Adult Trauma Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Editorial: Current advances in multimodal human brain imaging and analysis across the lifespan: From mapping to state prediction.Frontiers in neuroscience · 2023Article
- Childhood Threat Is Associated With Lower Resting-State Connectivity Within a Central Visceral Network.Frontiers in psychology · 2022Article
- Stressor-Specific Microbiota Intervention.Frontiers in nutrition · 2022Article
- Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology.Developmental cognitive neuroscience · 2021Article
- Opposing relationships of childhood threat and deprivation with stria terminalis white matter.Human brain mapping · 2021Article
- Early-life threat and deprivation: Are children similarly affected by exposure to each?Child developmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
While stress may be a potential mechanism by which childhood threat and deprivation influence mental health, few studies have considered specific stress-related white matter pathways, such as the stria terminalis (ST) and medial forebrain bundle (MFB). Our goal was to examine the relationships between childhood adversity and ST and MFB structural integrity and whether these pathways may provide a link between childhood adversity and affective symptoms and disorders. Participants were young adults (n = 100) with a full distribution of maltreatment history and affective symptom severity. Threat was determined by measures of childhood abuse and repeated traumatic events. Socioeconomic deprivation (SED) was determined by a measure of childhood socioeconomic status (parental education). Participants underwent diffusion spectrum imaging. Human Connectome Project data was used to perform ST and MFB tractography; these tracts were used as ROIs to extract generalized fractional anisotropy (gFA) from each participant. Childhood threat was associated with ST gFA, such that greater threat was associated with less ST gFA. SED was also associated with ST gFA, however, conversely to threat, greater SED was associated with greater ST gFA. Additionally, threat was negatively associated with MFB gFA, and MFB gFA was negatively associated with post-traumatic stress symptoms. Our results suggest that childhood threat and deprivation have opposing influences on ST structural integrity, providing new evidence that the context of childhood adversity may have an important influence on its neurobiological effects, even on the same structure. Further, the MFB may provide a novel link between childhood threat and affective symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.