Evidence map›Paper›PMID 33739540›Full record

ArticleHuman brain mapping2021

The emotional face of anorexia nervosa: The neural correlates of emotional processing.

Daniel Halls, Monica Leslie, Jenni Leppanen, Felicity Sedgewick, Simon Surguladze, Leon Fonville, Katie Lang, Mima Simic, Dasha Nicholls, Steven Williams and 1 more

Abstract read
In one paragraph

Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Are youPersonality neuroscience · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel HallsInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), Psychological Medicine, King's College London (KCL), London, UK.ORCID 0000-0002-5372-3179
Monica LeslieInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), Psychological Medicine, King's College London (KCL), London, UK.
Jenni LeppanenCentre for Neuroimaging Sciences, King's College London, London, UK.
Felicity SedgewickInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), Psychological Medicine, King's College London (KCL), London, UK.
Simon SurguladzeInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), Psychological Medicine, King's College London (KCL), London, UK.
Leon FonvilleDivision of Brain Sciences, Imperial College London, London, UK.
Katie LangKing's College London (KCL), Institute of Psychiatry, Psychology and Neuroscience (IoPPN), Department of Psychology, London, UK.
Mima SimicSouth London and Maudsley NHS Foundation Trust, London, UK.
Dasha NichollsDivision of Brain Sciences, Imperial College London, London, UK.
Steven WilliamsCentre for Neuroimaging Sciences, King's College London, London, UK.
Kate TchanturiaInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), Psychological Medicine, King's College London (KCL), London, UK.

Funding

Department of HealthMedical Research Council MR/R004595/1Medical Research Council MR/S020381/1
6 · The paper itself

Abstract

Social-emotional processing difficulties have been reported in Anorexia Nervosa (AN), yet the neural correlates remain unclear. Previous neuroimaging work is sparse and has not used functional connectivity paradigms to more fully explore the neural correlates of emotional difficulties. Fifty-seven acutely unwell AN (AAN) women, 60 weight-recovered AN (WR) women and 69 healthy control (HC) women categorised the gender of a series of emotional faces while undergoing Functional Magnetic Resonance Imaging. The mean age of the AAN group was 19.40 (2.83), WR 18.37 (3.59) and HC 19.37 (3.36). A whole brain and psychophysical interaction connectivity approach was used. Parameter estimates from significant clusters were extracted and correlated with clinical symptoms. Whilst no group level differences in whole brain activation were demonstrated, significant group level functional connectivity differences emerged. WR participants showed increased connectivity between the bilateral occipital face area and the cingulate, precentral gyri, superior, middle, medial and inferior frontal gyri compared to AAN and HC when viewing happy valenced faces. Eating disorder symptoms and parameter estimates were positively correlated. Our findings characterise the neural basis of social-emotional processing in a large sample of individuals with AN.

Indexed as

ConnectomeSocial PerceptionAdolescentAdultAnorexia NervosaCerebral CortexEmotionsFacial ExpressionFacial RecognitionFemaleHumansMagnetic Resonance ImagingYoung Adultanorexia nervosaemotional facesemotional processingfunctional magnetic resonance imaginingpsychophysical interaction

Identifiers

PMID33739540
PMCPMC8193512

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.