Evidence map›Paper›PMID 33739477›Full record

ArticleJournal of veterinary internal medicine2021

Presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog.

Emmanuelle Marie Butty, Shelley Hahn, Mary Anna Labato

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. BRAFVeterinary research communications · 2026
    Article
  2. Review
  3. Clinicopathologic Characterization of Prostatic Cancer in Dogs.Animals : an open access journal from MDPI · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emmanuelle Marie ButtyTufts University Cummings School of Veterinary Medicine, Internal Medicine, North Grafton, Massachusetts, USA.ORCID https://orcid.org/0000-0002-0797-3484
Shelley HahnTufts University Cummings School of Veterinary Medicine, Internal Medicine, North Grafton, Massachusetts, USA.
Mary Anna LabatoTufts University Cummings School of Veterinary Medicine, Internal Medicine, North Grafton, Massachusetts, USA.ORCID https://orcid.org/0000-0001-7871-2479
Tufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 3-year-old spayed female English Springer Spaniel was presented twice 4 months apart for investigation of hematuria and pollakiuria without urinary tract infection. Both ultrasound examinations identified a stable craniodorsal bladder wall thickening. The first cystoscopic biopsy samples indicated lymphoplasmacytic cystitis and the second polypoid cystitis. The dog was represented 8 months later for recurrent clinical signs despite medical management. Although the ultrasound examination showed stable disease, repeat cystoscopic biopsy identified transitional cell carcinoma (TCC), confirmed on tissue removed by partial cystectomy. No BRAF mutation was ever detected in urine or tissue samples. To our knowledge, this case represents the first report of presumptive malignant transformation of polypoid cystitis into an apical TCC in a dog. Dogs with polypoid cystitis should be followed closely and surgical management considered if rapid resolution is not achieved with medical management.

Indexed as

Carcinoma, Transitional CellCystitisDog DiseasesUrinary Bladder NeoplasmsAnimalsDogsFemaleMutationProto-Oncogene Proteins B-rafProto-Oncogene Proteins B-rafbladdercarcinoma in situurologyurothelial carcinoma

Identifiers

PMID33739477
PMCPMC8163141
OpenAlexW3137481495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.