Evidence map›Paper›PMID 33739401›Full record

ArticleGigaScience2021

Rapid development of cloud-native intelligent data pipelines for scientific data streams using the HASTE Toolkit.

Ben Blamey, Salman Toor, Martin Dahlö, Håkan Wieslander, Philip J Harrison, Ida-Maria Sintorn, Alan Sabirsh, Carolina Wählby, Ola Spjuth, Andreas Hellander

Abstract read
In one paragraph

Article in GigaScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ben BlameyDepartment of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.
Salman ToorDepartment of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.
Martin DahlöDepartment of Pharmaceutical Biosciences, Uppsala University, Husargatan 3, 75237, Uppsala, Sweden.
Håkan WieslanderDepartment of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.
Philip J HarrisonDepartment of Pharmaceutical Biosciences, Uppsala University, Husargatan 3, 75237, Uppsala, Sweden.
Ida-Maria SintornDepartment of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.
Alan SabirshAdvanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Carolina WählbyDepartment of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.
Ola SpjuthDepartment of Pharmaceutical Biosciences, Uppsala University, Husargatan 3, 75237, Uppsala, Sweden.
Andreas HellanderDepartment of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLarge streamed datasets, characteristic of life science applications, are often resource-intensive to process, transport and store. We propose a pipeline model, a design pattern for scientific pipelines, where an incoming stream of scientific data is organized into a tiered or ordered "data hierarchy". We introduce the HASTE Toolkit, a proof-of-concept cloud-native software toolkit based on this pipeline model, to partition and prioritize data streams to optimize use of limited computing resources.

findingsIn our pipeline model, an "interestingness function" assigns an interestingness score to data objects in the stream, inducing a data hierarchy. From this score, a "policy" guides decisions on how to prioritize computational resource use for a given object. The HASTE Toolkit is a collection of tools to adopt this approach. We evaluate with 2 microscopy imaging case studies. The first is a high content screening experiment, where images are analyzed in an on-premise container cloud to prioritize storage and subsequent computation. The second considers edge processing of images for upload into the public cloud for real-time control of a transmission electron microscope.

conclusionsThrough our evaluation, we created smart data pipelines capable of effective use of storage, compute, and network resources, enabling more efficient data-intensive experiments. We note a beneficial separation between scientific concerns of data priority, and the implementation of this behaviour for different resources in different deployment contexts. The toolkit allows intelligent prioritization to be `bolted on' to new and existing systems - and is intended for use with a range of technologies in different deployment scenarios.

Indexed as

Biological Science DisciplinesSoftwareDiagnostic ImagingHASTEimage analysisinterestingness functionsstream processingtiered storage

Identifiers

PMID33739401
PMCPMC7976223

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.