Evidence map›Paper›PMID 33739396›Full record

ReviewBioscience reports2021

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications.

Xiuxiu Wang, Xiaoyue Shen, Yuting Yan, Hongmin Li

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioscience reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 141 citations in OpenAlex.

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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xiuxiu WangProvincial Key Laboratory of Biotechnology of Shaanxi, College of Life Sciences, Northwest University, Taibai North Rd 229, Xi'an, Shaanxi Province 710069, China.
Xiaoyue ShenProvincial Key Laboratory of Biotechnology of Shaanxi, College of Life Sciences, Northwest University, Taibai North Rd 229, Xi'an, Shaanxi Province 710069, China.
Yuting YanProvincial Key Laboratory of Biotechnology of Shaanxi, College of Life Sciences, Northwest University, Taibai North Rd 229, Xi'an, Shaanxi Province 710069, China.
Hongmin LiProvincial Key Laboratory of Biotechnology of Shaanxi, College of Life Sciences, Northwest University, Taibai North Rd 229, Xi'an, Shaanxi Province 710069, China.
Northwest University · CNMinistry of Education of the People's Republic of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it further links glycolysis with the tricarboxylic acid cycle and ATP generation. This review seeks to elucidate the regulation of PDK activity in different species, mainly mammals, and the role of PDK inhibitors in preventing increased blood glucose, reducing injury caused by myocardial ischemia, and inducing apoptosis of tumor cells. Regulations of PDKs expression or activity represent a very promising approach for treatment of metabolic diseases including diabetes, heart failure, and cancer. The future research and development could be more focused on the biochemical understanding of the diseases, which would help understand the cellular energy metabolism and its regulation by pharmacological effectors of PDKs.

Indexed as

AnimalsCardiovascular DiseasesDiabetes MellitusHumansNeoplasmsPyruvate Dehydrogenase ComplexPyruvate Dehydrogenase Complexpyruvatepyruvate dehydrogenase complexpyruvate dehydrogenase kinase

Identifiers

PMID33739396
PMCPMC8026821
OpenAlexW3137707528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.