Evidence map›Paper›PMID 33739254›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2021

Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.

Daniel J Grint, Kevin Wing, Elizabeth Williamson, Helen I McDonald, Krishnan Bhaskaran, David Evans, Stephen Jw Evans, Alex J Walker, George Hickman, Emily Nightingale and 26 more

Abstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Hyperimmune immunoglobulin for people with COVID-19.The Cochrane database of systematic reviews · 2023
    Pooled it
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  18. Lung fibrosis: Post-COVID-19 complications and evidences.International immunopharmacology · 2023
    Review
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  20. Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Daniel J GrintFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Kevin WingFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Elizabeth WilliamsonFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Helen I McDonaldFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Krishnan BhaskaranFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
David EvansThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Stephen Jw EvansFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Alex J WalkerThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
George HickmanThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Emily NightingaleFaculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Anna SchultzeFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Christopher T RentschFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Chris BatesThe Phoenix Partnership (TPP), TPP House, Leeds, United Kingdom.
Jonathan CockburnThe Phoenix Partnership (TPP), TPP House, Leeds, United Kingdom.
Helen J CurtisThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Caroline E MortonThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Sebastian BaconThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Simon DavyThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Angel Ys WongFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Amir MehrkarThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Laurie TomlinsonFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Ian J DouglasFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Rohini MathurFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Paula BlomquistCOVID-19 Outbreak Surveillance Team, Public Health England, London, United Kingdom.
Brian MacKennaThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Peter IngelsbyThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Richard CrokerThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
John ParryThe Phoenix Partnership (TPP), TPP House, Leeds, United Kingdom.
Frank HesterThe Phoenix Partnership (TPP), TPP House, Leeds, United Kingdom.
Sam HarperThe Phoenix Partnership (TPP), TPP House, Leeds, United Kingdom.
Nicholas J DeVitoThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Will HulmeThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
John TazareFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Ben GoldacreThe DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Liam SmeethFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Rosalind M EggoFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Funding

Medical Research Council MC_PC_19065Medical Research Council MR/R010161/1Medical Research Council MR/V015737/1
6 · The paper itself

Abstract

The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34-2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.

Indexed as

Age FactorsComorbidityCOVID-19EnglandHumansSARS-CoV-2Case fatality riskCFRCoronavirusCOVID-19MortalitySARS-CoV-2Variant of concern

Identifiers

PMID33739254
PMCPMC7976383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.