Evidence map›Paper›PMID 33739214›Full record

ArticleInternational journal of stroke : official journal of the International Stroke Society2022

International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery.

Arne G Lindgren, Robynne G Braun, Jennifer Juhl Majersik, Philip Clatworthy, Shraddha Mainali, Colin P Derdeyn, Jane Maguire, Christina Jern, Jonathan Rosand, John W Cole and 19 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in International journal of stroke : official journal of the International Stroke Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Associations between admission levels of multiple biomarkers and subsequent worse outcomes in acute ischemic stroke patients.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Collateral Flow: Prolonging the Ischemic Penumbra.Translational stroke research · 2023
    Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 10 countries.

Arne G LindgrenDepartment of Clinical Sciences Lund, Neurology, 5193-->Lund University, Lund, Sweden.ORCID 0000-0003-1942-7330
Robynne G BraunDepartment of Neurology, University of Maryland, Baltimore, MD, USA.
Jennifer Juhl MajersikDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Philip ClatworthyDepartment of Neurology, North Bristol NHS Trust, Bristol, UK.
Shraddha MainaliDepartment of Neurology, 2647-->The Ohio State University, Columbus, OH, USA.
Colin P DerdeynDepartment of Radiology, University of Iowa, Iowa City, IA, USA.
Jane MaguireFaculty of Health, University of Technology Sydney, Ultimo, NSW, Australia.
Christina JernDepartment of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Jonathan RosandDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
John W ColeNeurology Service, Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA.
Jin-Moo LeeDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Pooja KhatriDepartment of Neurology and Rehabilitation Sciences, University of Cincinnati, Cincinnati, OH, USA.
Paul NyquistNeurology, Anesthesiology/Critical Care Medicine, Neurosurgery, and General Internal Medicine, 1500-->Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6078-3543
Stéphanie DebetteBordeaux Population Health, Inserm U1219, University of Bordeaux, Bordeaux, France.
Loo Keat WeiDepartment of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak, Malaysia.
Tatjana RundekDepartment of Neurology, 12235-->University of Miami Miller School of Medicine, Miami, FL, USA.
Dana LeiferDepartment of Neurology, Weill Cornell Medicine, New York, NY, USA.
Vincent ThijsStroke Theme, Florey Institute of Neuroscience and Mental Health, Melbourne, Vic, Australia.ORCID 0000-0002-6614-8417
Robin LemmensDepartment of Neuroscience, University of Leuven, Leuven, Belgium.
Laura HeitschDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Kameshwar PrasadRajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Jordi Jimenez CondeNeurology Department, Neurovascular Research Group, Institut Hospital del Mar d'Investigació Mèdica, Barcelona, Spain.
Martin DichgansInstitute for Stroke and Dementia Research, University Hospital, LMU, Munich, Germany.
Natalia S RostDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Steven C CramerDepartment of Neurology, UCLA, Los Angeles, CA, USA.
Julie BernhardtStroke Theme, Florey Institute of Neuroscience and Mental Health, Melbourne, Vic, Australia.ORCID 0000-0002-2787-8484
Bradford B WorrallDepartment of Neurology, University of Virginia, Charlottesville, VA, USA.
Israel Fernandez-CadenasStroke Pharmacogenomics and Genetics Group, Sant Pau Biomedical Research Institute, Barcelona, Spain.
International Stroke Genetics Consortium
Florey Institute of Neuroscience and Mental Health · AUMassachusetts General Hospital · USUniversity of Maryland, Baltimore · USWashington University in St. Louis · USCornell University · USHospital de Sant Pau · ESJohns Hopkins University · USKU Leuven · BELudwig-Maximilians-Universität München · DELund University · SENorth Bristol NHS Trust · GBRajendra Memorial Research Institute of Medical Sciences · INSahlgrenska University Hospital · SEThe Ohio State University · USUniversitat Autònoma de Barcelona · ESUniversité de Bordeaux · FRUniversiti Tunku Abdul Rahman · MYUniversity of California, Los Angeles · USUniversity of Cincinnati · USUniversity of Iowa · US

Funding

DISCOVERY - Statistics and Analysis CoreU19NS115388 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Steven M Greenberg, Natalia S Rost · 2019 to 2026
$75.4M
Institutional Career Development CoreKL2TR003016 · NCATS · UNIVERSITY OF VIRGINIA · PI PAPIN, JASON, WORRALL, BRADFORD B · 2019 to 2023
$3.9M
Neurorehabilitation and Restorative Neuroscience NetworkK12HD093427 · NICHD · GEORGETOWN UNIVERSITY · PI BREGMAN, BARBARA S, DROMERICK, ALEXANDER W · 2017 to 2021
$3.9M
MRI-GENetics Interface Exploration_MRI-GENIE_StudyR01NS086905 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROST, NATALIA S · 2015 to 2019
$3.3M
Stroke Trials Network of Columbia and CornellU24NS107237 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EDWARD SANDER CONNOLLY, Randolph S Marshall · 2018 to 2026
$3.1M
Genetics of ischemic stroke in the SiGN ConsortiumR01NS100178 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2017 to 2021
$3.0M
Genetics of Early-Onset Ischemic Stroke ConsortiumR01NS105150 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2018 to 2022
$3.0M
Genetic Architecture of Acute Human Brain IschemiaR01NS085419 · NINDS · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS, LEE, JIN-MOO · 2014 to 2018
$2.8M
Mid-America Regional Coordinating Center (MARCC)U24NS107230 · NINDS · WASHINGTON UNIVERSITY · PI Andria Lee Ford, Peter David Panagos · 2018 to 2026
$2.8M
Statins augment small vessel function and improve stroke outcomesR01NS082285 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROST, NATALIA S · 2013 to 2017
$2.6M
Stroke Central Atlantic Network for Research (SCANR)U24NS107222 · NINDS · MEDSTAR HEALTH RESEARCH INSTITUTE · PI Amie Hsia, Peter Ethan Turkeltaub · 2018 to 2026
$2.6M
CNV And Stroke (CaNVAS)R01NS114045 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI COLE, JOHN W. · 2020 to 2024
$2.6M
NCATS NIH HHS KL2 TR003016NICHD NIH HHS K12 HD093427NINDS NIH HHS K23 NS099487NINDS NIH HHS R01 NS082285NINDS NIH HHS R01 NS085419NINDS NIH HHS R01 NS086905NINDS NIH HHS R01 NS100178NINDS NIH HHS R01 NS105150NINDS NIH HHS R01 NS114045NINDS NIH HHS R21 NS106480NINDS NIH HHS U10 NS086606NINDS NIH HHS U19 NS115388NINDS NIH HHS U24 NS107222NINDS NIH HHS U24 NS107230NINDS NIH HHS U24 NS107237
6 · The paper itself

Abstract

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.

Indexed as

Brain InjuriesStrokeStroke RehabilitationData CollectionHumansPhenotypeRecovery of FunctionData collectiongeneticsischemic strokeoutcomephenotyperecoverystandardization

Identifiers

PMID33739214
PMCPMC8864333
OpenAlexW3136632973

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.