Evidence map›Paper›PMID 33739024›Full record

ArticleScientific reports2021

Long-term treated HIV infection is associated with platelet mitochondrial dysfunction.

Wouter A van der Heijden, Lisa van de Wijer, Martin Jaeger, Karin Grintjes, Mihai G Netea, Rolf T Urbanus, Reinout van Crevel, Lambertus P van den Heuvel, Maaike Brink, Richard J Rodenburg and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  5. Article
  6. Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025
    Review
  7. Article
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  18. Article
  19. Platelet Innate Immune Receptors and TLRs: A Double-Edged Sword.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Wouter A van der HeijdenDepartment of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands. Wouter.vanderHeijden@radboudumc.nl.
Lisa van de WijerDepartment of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
Martin JaegerDepartment of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
Karin GrintjesDepartment of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
Mihai G NeteaDepartment of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
Rolf T UrbanusDepartment of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Reinout van CrevelDepartment of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
Lambertus P van den HeuvelDepartment of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Maaike BrinkTranslational Metabolic Laboratory, Department Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Richard J RodenburgDepartment of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Philip G de GrootDepartment of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
Andre J van der VenDepartment of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
Quirijn de MastDepartment of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
Radboud University Medical Center · NLRadboud University Nijmegen · NLUniversity of Bonn · DEUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV infection and antiretroviral therapy have been linked to mitochondrial dysfunction. The role of platelet mitochondrial dysfunction in thrombosis, immunoregulation and age-related diseases is increasingly appreciated. Here, we studied platelet mitochondrial DNA content (mtDNA

Indexed as

HIV-1AdultAnti-HIV AgentsBlood PlateletsCase-Control StudiesCross-Sectional StudiesDNA, MitochondrialFemaleHIV InfectionsHumansMaleMiddle AgedMitochondriaNetherlandsOxygen ConsumptionPlatelet ActivationAnti-HIV AgentsDNA, MitochondrialZidovudine

Identifiers

PMID33739024
PMCPMC7973809
OpenAlexW3136805858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.