Evidence map›Paper›PMID 33739023›Full record

ArticleScientific reports2021

The effects of the miR-21/SMAD7/TGF-β pathway on Th17 cell differentiation in COPD.

Shengyang He, Shenghua Sun, Junjuan Lu, Lili Chen, Xiang Mei, Liqiu Li, Zhengpeng Zeng, Mubin Zhong, Lihua Xie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  14. The role of Th17 cells: explanation of relationship between periodontitis and COPD?Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shengyang HeDepartment of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
Shenghua SunDepartment of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
Junjuan LuDepartment of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
Lili ChenDepartment of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
Xiang MeiDepartment of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
Liqiu LiDepartment of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
Zhengpeng ZengDepartment of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
Mubin ZhongDepartment of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
Lihua XieDepartment of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China. xyelyhua@163.com.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a complex disease with multiple etiologies, while smoking is the most established one. The present study investigated the modulation of T-helper 17 (Th17) cell differentiation by the miR-21/Smad7/TGF-β pathway, and their roles in COPD. Lung tissues were obtained from lung cancer patients with or without COPD who underwent lobotomy and the levels of miR-21, TGF-β/Smad signaling molecules, RORγT, and other Th17-related cytokines were detected. Mouse COPD models were built by exposing both wild-type (WT) and miR-21

Indexed as

AnimalsCD4-Positive T-LymphocytesCell DifferentiationCigarette SmokingDisease Models, AnimalHumansLungLung NeoplasmsLymphocyte ActivationMiceMicroRNAsNuclear Receptor Subfamily 1, Group F, Member 3Pulmonary Disease, Chronic ObstructiveSignal TransductionSmad7 ProteinSmokeMicroRNAsMIRN21 microRNA, humanMIRN21 microRNA, mouseNuclear Receptor Subfamily 1, Group F, Member 3RORC protein, humanSmad7 ProteinSmokeTransforming Growth Factor beta

Identifiers

PMID33739023
PMCPMC7973755
OpenAlexW3138867835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.