Evidence map›Paper›PMID 33739022›Full record

ArticleScientific reports2021

Confirmation of the cardiac safety of nolasiban in a randomised cohort of healthy female volunteers.

Jörg Täubel, Ulrike Lorch, Christopher S Spencer, Anne Freier, Dorothée Camilleri, Dilshat Djumanov, Georg Ferber, Line Marchand, Jean-Pierre Gotteland, Oliver Pohl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Jörg TäubelRichmond Pharmacology Ltd., St George's University of London, Cranmer Terrace, London, SW17 0RE, UK. j.taubel@richmondpharmacology.com.
Ulrike LorchRichmond Pharmacology Ltd., St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.
Christopher S SpencerRichmond Research Institute, St George's University of London, London, UK.
Anne FreierRichmond Research Institute, St George's University of London, London, UK.
Dorothée CamilleriRichmond Pharmacology Ltd., St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.
Dilshat DjumanovRichmond Pharmacology Ltd., St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.
Georg FerberStatistik Georg Ferber GmbH, Riehen, Switzerland.
Line MarchandObsEva SA, Geneva, Switzerland.
Jean-Pierre GottelandObsEva SA, Geneva, Switzerland.
Oliver PohlObsEva SA, Geneva, Switzerland.
St George's, University of London · GBObsEva (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nolasiban is an orally active oxytocin receptor antagonist being developed to increase the efficiency of assisted reproductive technologies. This study evaluated the pharmacokinetics, pharmacodynamics, and cardiac safety of nolasiban in 45 healthy women of child-bearing age. Nolasiban was administered in a fasted state with a standardised lunch served 4.5 h post-dose. Concentration-effect modelling was used to assess the effect of two dosages of nolasiban (900 mg and 1800 mg) on QTc following single-dose administration. We found no significant change in QTc at all tested dosages. Two-sided 90% confidence intervals of geometric mean C

Indexed as

AdultCohort StudiesDose-Response Relationship, DrugElectrocardiographyFemaleHealthy VolunteersHeartHeart RateHumansOximesPyrrolidinesReceptors, OxytocinReproductive Techniques, AssistedYoung AdultnolasibanOximesOXTR protein, humanPyrrolidinesReceptors, Oxytocin

Identifiers

PMID33739022
PMCPMC7973531
OpenAlexW3138192281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.