ArticleAdvanced healthcare materials2021
Stabilization of Damaged Articular Cartilage with Hydrogel-Mediated Reinforcement and Sealing.
Article in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Liposomal multimodal theranostics for bone disorders: from rational responsive delivery and biomimetic strategies to clinical translation.Journal of nanobiotechnology · 2026Review
- Exploring mechanisms governing cartilage interstitial fluid load support in lubrication through experimental and computational analysis.Scientific reports · 2026Article
- Cationic hydrogel with sustained lubrication and anti-calcification for osteoarthritis therapy.Journal of nanobiotechnology · 2026Article
- Rapid restoration of cell phenotype and matrix forming capacity following transient nuclear softening.Acta biomaterialia · 2025Article
- Mechanical Wear of Degraded Articular Cartilage.Annals of biomedical engineering · 2025Article
- Exogenous Collagen Crosslinking is Highly Detrimental to Articular Cartilage Lubrication.Journal of biomechanical engineering · 2024Article
- Dual-Modified Hyaluronic Acid for Tunable Double Cross-Linked Hydrogel Adhesives.Biomacromolecules · 2024Article
- Emerging advances in hydrogel-based therapeutic strategies for tissue regeneration.Regenerative therapy · 2023Review
- DMTMM-mediated synthesis of norbornene-modified hyaluronic acid polymers to probe cell-hydrogel interactions.Carbohydrate polymer technologies and applications · 2023Article
- Improved Cartilage Protection with Low Molecular Weight Hyaluronic Acid Hydrogel.Bioengineering (Basel, Switzerland) · 2023Article
- Yes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes.Osteoarthritis and cartilage · 2023Article
- In Vitro Analysis of Human Cartilage Infiltrated by Hydrogels and Hydrogel-Encapsulated Chondrocytes.Bioengineering (Basel, Switzerland) · 2023Article
- Correlation analysis of cartilage wear with biochemical composition, viscoelastic properties and friction.Journal of the mechanical behavior of biomedical materials · 2023Article
- The Biomechanical Influence of Defected Cartilage on the Progression of Osteochondral Lesions of the Talus: A Three-dimensional Finite Element Analysis.Orthopaedic surgery · 2023Article
- Linguistic Analysis Identifies Emergent Biomaterial Fabrication Trends for Orthopaedic Applications.Advanced healthcare materials · 2023Review
- Progress and prospect of technical and regulatory challenges on tissue-engineered cartilage as therapeutic combination product.Bioactive materials · 2023Review
- PEG Reinforced Scaffold Promotes Uniform Distribution of Human MSC-Created Cartilage Matrix.Gels (Basel, Switzerland) · 2022Article
- Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.Nature communications · 2022Article
- A Co-Polymerizable Linker for the Covalent Attachment of Fibronectin Makes pHEMA Hydrogels Cell-Adhesive.Gels (Basel, Switzerland) · 2022Article
- Effect of viscoelastic properties of cellulose nanocrystal/collagen hydrogels on chondrocyte behaviors.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Cartilage injuries and subsequent tissue deterioration impact millions of patients. Since the regeneration of functional hyaline cartilage remains elusive, methods to stabilize the remaining tissue, and prevent further deterioration, would be of significant clinical utility and prolong joint function. Finite element modeling shows that fortification of the degenerate cartilage (Reinforcement) and reestablishment of a superficial zone (Sealing) are both required to restore fluid pressurization within the tissue and restrict fluid flow and matrix loss from the defect surface. Here, a hyaluronic acid (HA) hydrogel system is designed to both interdigitate with and promote the sealing of the degenerated cartilage. Interdigitating fortification restores both bulk and local pericellular tissue mechanics, reestablishing the homeostatic mechanotransduction of endogenous chondrocytes within the tissue. This HA therapy is further functionalized to present chemo mechanical cues that improve the attachment and direct the response of mesenchymal stem/stromal cells at the defect site, guiding localized extracellular matrix deposition to "seal" the defect. Together, these results support the therapeutic potential, across cell and tissue length scales, of an innovative hydrogel therapy for the treatment of damaged cartilage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.