Evidence map›Paper›PMID 33738974›Full record

ArticleAdvanced healthcare materials2021

Facile Synthesis of a Croconaine-Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy.

Nian Liu, Patrick O'Connor, Vipul Gujrati, Dimitris Gorpas, Sarah Glasl, Andreas Blutke, Axel Walch, Karin Kleigrewe, Michael Sattler, Oliver Plettenburg and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 60 citations in OpenAlex.

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  12. In vivo optical molecular imaging of inflammation and immunity.Journal of molecular medicine (Berlin, Germany) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Nian LiuChair of Biological Imaging, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, 81675, Germany.
Patrick O'ConnorInstitute of Medicinal Chemistry, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.
Vipul GujratiChair of Biological Imaging, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, 81675, Germany.ORCID 0000-0003-2586-0210
Dimitris GorpasChair of Biological Imaging, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, 81675, Germany.
Sarah GlaslInstitute of Biological and Medical Imaging, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.
Andreas BlutkeResearch Unit Analytical Pathology, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.
Axel WalchResearch Unit Analytical Pathology, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.
Karin KleigreweBavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich, Freising, 85354, Germany.
Michael SattlerInstitute of Structural Biology, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.
Oliver PlettenburgInstitute of Medicinal Chemistry, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.
Vasilis NtziachristosChair of Biological Imaging, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, 81675, Germany.ORCID 0000-0002-9988-0233
Helmholtz Zentrum München · DECenter for Integrated Protein Science Munich · DELeibniz University Hannover · DETechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Near-infrared (NIR) light absorbing theranostic agents can integrate optoacoustic imaging and photothermal therapy for effective personalized precision medicine. However, most of these agents face the challenges of unstable optical properties, material-associated toxicity, and nonbiodegradability, all of which limit their biomedical application. Several croconaine-based organic agents able to overcome some of these limitations have been recently reported, but these suffer from complicated multistep synthesis protocols. Herein, the use of CR760, a croconaine dye with excellent optical properties, is reported for nanoparticle formulation and subsequent optoacoustic imaging and photothermal therapy. Importantly, CR760 can be conveniently prepared in a single step from commercially available materials. Furthermore, CR760 can be covalently attached, via a polyethylene glycol linker, to the α

Indexed as

NanoparticlesNeoplasmsPhotoacoustic TechniquesAnimalsMicePhototherapyPhotothermal TherapyTheranostic Nanomedicinecroconainenanoparticlesoptoacousticsphotothermal therapy

Identifiers

PMID33738974
PMCPMC11469157
OpenAlexW3139223275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.