Evidence map›Paper›PMID 33738966›Full record

ArticleAdvanced healthcare materials2021

Mechanobiological Interactions between Dynamic Compressive Loading and Viscoelasticity on Chondrocytes in Hydrazone Covalent Adaptable Networks for Cartilage Tissue Engineering.

Benjamin M Richardson, Cierra J Walker, Mollie M Maples, Mark A Randolph, Stephanie J Bryant, Kristi S Anseth

Open access · greenAbstract read
In one paragraph

Article in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Hydrogel Design to Understand and Guide 3D Cell Migration.Regenerative engineering and translational medicine · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Frontiers in bioengineering and biotechnology · 2024
    Article
  11. Article
  12. Article
  13. Mimicking Loading-Induced Cartilage Self-HeatingACS biomaterials science & engineering · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Benjamin M RichardsonDepartment of Chemical and Biological Engineering, University of Colorado Boulder, 3415 Colorado Ave, Boulder, CO, 80303, USA.
Cierra J WalkerThe BioFrontiers Institute, University of Colorado Boulder, 3415 Colorado Ave, Boulder, CO, 80303, USA.
Mollie M MaplesDepartment of Chemical and Biological Engineering, University of Colorado Boulder, 3415 Colorado Ave, Boulder, CO, 80303, USA.
Mark A RandolphDepartment of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, WAC 435, Boston, MA, 02114, USA.
Stephanie J BryantDepartment of Chemical and Biological Engineering, University of Colorado Boulder, 3415 Colorado Ave, Boulder, CO, 80303, USA.
Kristi S AnsethDepartment of Chemical and Biological Engineering, University of Colorado Boulder, 3415 Colorado Ave, Boulder, CO, 80303, USA.ORCID 0000-0002-5725-5691
University of Colorado Boulder · USHarvard University · US

Funding

Osteogenic Hydrogel Niches to Promote hMSC Migration and DifferentiationR01DE016523 · NIDCR · UNIVERSITY OF COLORADO AT BOULDER · PI ANSETH, KRISTI S. · 2005 to 2023
$6.2M
Synthetic hydrogels to study formation and maintenance of intestinal cryptsR01DK120921 · NIDDK · UNIVERSITY OF COLORADO · PI KRISTI S. ANSETH, PETER J DEMPSEY · 2019 to 2026
$3.8M
Understanding valvular fibroblast mechanical memory using photo-tunable PEG hydrogelsF31HL142223 · NHLBI · UNIVERSITY OF COLORADO · PI WALKER, CIERRA · 2018 to 2020
$107k
NHLBI NIH HHS F31 HL142223NIDCR NIH HHS R01 DE016523NIDDK NIH HHS R01 DK120921NIH HHS R01 DE016523NIH HHS R01 DK120921NIH Predoctoral F31HL142223
6 · The paper itself

Abstract

Mechanobiological cues influence chondrocyte biosynthesis and are often used in tissue engineering applications to improve the repair of articular cartilage in load-bearing joints. In this work, the biophysical effects of an applied dynamic compression on chondrocytes encapsulated in viscoelastic hydrazone covalent adaptable networks (CANs) is explored. Here, hydrazone CANs exhibit viscoelastic loss tangents ranging from (9.03 ± 0.01) 10

Indexed as

Cartilage, ArticularChondrocytesCompressive StrengthHydrazonesStress, MechanicalTissue EngineeringHydrazonescartilage tissue engineeringcovalent adaptable networksdynamic loadinghydrazonesviscoelasticity

Identifiers

PMID33738966
PMCPMC8785214
OpenAlexW3138442713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.