Evidence map›Paper›PMID 33738957›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2021

A Theranostic Cellulose Nanocrystal-Based Drug Delivery System with Enhanced Retention in Pulmonary Metastasis of Melanoma.

Surachet Imlimthan, You Cheng Khng, Outi Keinänen, Wenzhong Zhang, Anu J Airaksinen, Mauri A Kostiainen, Brian M Zeglis, Hélder A Santos, Mirkka Sarparanta

Open access · hybridAbstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Surachet ImlimthanDepartment of Chemistry, University of Helsinki, Helsinki, FI-00014, Finland.ORCID 0000-0003-2520-2146
You Cheng KhngDepartment of Chemistry, University of Helsinki, Helsinki, FI-00014, Finland.ORCID 0000-0003-2445-136X
Outi KeinänenDepartment of Chemistry, University of Helsinki, Helsinki, FI-00014, Finland.ORCID 0000-0002-3939-6706
Wenzhong ZhangDepartment of Chemistry, University of Helsinki, Helsinki, FI-00014, Finland.ORCID 0000-0001-9184-0723
Anu J AiraksinenDepartment of Chemistry, University of Helsinki, Helsinki, FI-00014, Finland.ORCID 0000-0002-5943-3105
Mauri A KostiainenBiohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, Aalto, FI-00076, Finland.ORCID 0000-0002-8282-2379
Brian M ZeglisDepartment of Chemistry, Hunter College, The City University of New York, New York, NY, 10021, USA.ORCID 0000-0002-9091-744X
Hélder A SantosDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.ORCID 0000-0001-7850-6309
Mirkka SarparantaDepartment of Chemistry, University of Helsinki, Helsinki, FI-00014, Finland.ORCID 0000-0002-2956-4366
University of Helsinki · FIAalto University · FIMemorial Sloan Kettering Cancer Center · USThe Graduate Center, CUNY · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Pretargeted Clinical Imaging of CA19.9 in Pancreatic CancerU01CA221046 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ZEGLIS, BRIAN MATTHEW · 2018 to 2022
$3.5M
Novel Reagents for Rapid and Stable Thiol-Based BioconjugationsR01CA240963 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2019 to 2023
$1.6M
A PET Radiotracer for Diagnostic and Theranostics Imaging in Lyme DiseaseR21EB030275 · NIBIB · HUNTER COLLEGE · PI QIU, WEIGANG, ZEGLIS, BRIAN MATTHEW · 2020 to 2021
$429k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA240963NCI NIH HHS U01 CA221046NIBIB NIH HHS R21 EB030275
6 · The paper itself

Abstract

Metastatic melanoma can be difficult to detect until at the advanced state that decreases the survival rate of patients. Several FDA-approved BRAF inhibitors have been used for treatment of metastatic melanoma, but overall therapeutic efficacy has been limited. Lutetium-177 (

Indexed as

MelanomaNanoparticlesAnimalsCell Line, TumorCelluloseDrug Delivery SystemsHumansMicePrecision MedicineTissue DistributionCellulosecellulose nanocrystaldrug delivery systemLutetium-177metastatic melanomatheranostic nanosystemvemurafenib

Identifiers

PMID33738957
PMCPMC8175021
OpenAlexW3132023065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.