Evidence map›Paper›PMID 33738706›Full record

ReviewProbiotics and antimicrobial proteins2021

Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics.

Konstantin A Demin, Aleksandr G Refeld, Anna A Bogdanova, Evgenya V Prazdnova, Igor V Popov, Olga Yu Kutsevalova, Alexey M Ermakov, Anzhelica B Bren, Dmitry V Rudoy, Vladimir A Chistyakov and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Probiotics and antimicrobial proteins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
  6. Article
  7. Anti-Antibiotics (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Konstantin A Demin *Academy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia.ORCID http://orcid.org/0000-0003-1853-0475
Aleksandr G Refeld *Academy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia.ORCID http://orcid.org/0000-0003-1856-4069
Anna A BogdanovaAcademy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia.ORCID http://orcid.org/0000-0001-6497-1648
Evgenya V PrazdnovaAcademy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia.ORCID http://orcid.org/0000-0001-7823-9044
Igor V PopovCenter for Agrobiotechnology, Don State Technical University, Rostov-on-Don, Russia.ORCID http://orcid.org/0000-0002-9223-8731
Olga Yu KutsevalovaNational Medical Research Centre for Oncology, Rostov-on-Don, Russia.ORCID http://orcid.org/0000-0001-7452-6994
Alexey M ErmakovCenter for Agrobiotechnology, Don State Technical University, Rostov-on-Don, Russia.ORCID http://orcid.org/0000-0002-9834-3989
Anzhelica B BrenAcademy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia.ORCID http://orcid.org/0000-0002-7452-6203
Dmitry V RudoyCenter for Agrobiotechnology, Don State Technical University, Rostov-on-Don, Russia.ORCID http://orcid.org/0000-0002-1916-8570
Vladimir A ChistyakovAcademy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia.ORCID http://orcid.org/0000-0002-2596-0855
Richard WeeksHealth Promoting Naturals Laboratory, School of Environmental and Biological Sciences, Rutgers State University, New Brunswick, NJ, USA.
Michael L ChikindasCenter for Agrobiotechnology, Don State Technical University, Rostov-on-Don, Russia. tchikind@sebs.rutgers.edu.ORCID http://orcid.org/0000-0001-7265-4562
Southern Federal University · RUDon State Technical University · RURutgers, The State University of New Jersey · USRostov Research Institute of Oncology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic Candida and infections caused by those species are now considered as a serious threat to public health. The treatment of candidiasis is significantly complicated by the increasing resistance of pathogenic strains to current treatments and the stagnant development of new antimycotic drugs. Many species, such as Candida auris, have a wide range of resistance mechanisms. Among the currently used synthetic and semi-synthetic antifungal drugs, the most effective are azoles, echinocandins, polyenes, nucleotide analogs, and their combinations. However, the use of probiotic microorganisms and/or the compounds they produce is quite promising, although underestimated by modern pharmacology, to control the spread of pathogenic Candida species.

Indexed as

Drug Resistance, FungalProbioticsAntifungal AgentsCandidaCandida aurisAntifungal AgentsAntifungal drugsBiofilm formationCandidaProbioticsResistance

Identifiers

PMID33738706
OpenAlexW3137201670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.