SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Functional autonomy in dementia of the Alzheimer's type, mild cognitive impairment, and healthy aging: a meta-analysis.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- The relation between cognitive functioning and activities of daily living in normal aging, mild cognitive impairment, and dementia: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Association Between Activities of Daily Living Profiles and Memory Decline in Community-Dwelling Older Adults Without Cognitive Impairment: An Observational Panel Study.Journal of advanced nursing · 2026Observational
- Facilitators and Barriers to Over-the-Counter Hearing Aid Use in People With Dementia: Semistructured Interview Study.JMIR human factors · 2026Article
- Differential Effects of Lifestyle Indicators on Cognitive Functioning Across Healthy, Dementia, Parkinson's Disease, and Stroke Groups.Journal of clinical medicine · 2026Article
- Functional autonomy, comorbidities and cognitive decline: a mediation analysis in neurocognitive disorders.Frontiers in aging neuroscience · 2026Article
- IADL for identifying cognitive impairment in Chinese older adults: insights from cross-lagged panel network analysis.BMC geriatrics · 2025Article
- Current status and future directions for the diagnosis and management of mild cognitive impairment in Southeast Asia: A SEACURE consensus paper.The journal of prevention of Alzheimer's disease · 2025Article
- Concurrent Validity of Performance-Based Measures of Daily Functioning with Cognitive Measures and Informant Reported Everyday Functioning.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Cognitive performance classification of older patients using machine learning and electronic medical records.Scientific reports · 2025Article
- Cognitive impairment in CKD patients: a guidance document by the CONNECT network.Clinical kidney journal · 2025Review
- The Impact of Prior Incarceration on Cognitive Trajectories Among Older Adults: Evidence From the Health and Retirement Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Social support and aging: psychometric analysis of the ENRICHD Social Support Instrument in a Chilean population over 50.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2025Article
- Comparison of robustness, resilience and intrinsic capacity including prediction of long-term adverse health outcomes: The KORA-Age study.The journal of nutrition, health & aging · 2025Article
- Functional training improves cognitive function, functional fitness, and BDNF levels in older women with mild cognitive impairment: a randomized controlled trial.Frontiers in physiology · 2025Article
- Characteristics of the Japanese version of the Alzheimer's Disease Cooperative Study Scale for Activities of Daily Living in Mild Cognitive Impairment (ADCS-MCI-ADL-J): preliminary data.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2025Article
- Factors associated with the occupational balance in caregivers of people with dementia: A cross-sectional study from the ATENEA project.BMC geriatrics · 2024Article
- Prior Incarceration and Performance on Immediate and Delayed Verbal Recall Tests: Results From National Longitudinal Study of Adolescent to Adult Health-Parent Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Memory Support System in French: a Pilot Study.Canadian geriatrics journal : CGJ · 2024Article
- Social Isolation and Loneliness in a Population Study of Cognitive Impairment: The MYHAT Study.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2023Article
- Mesoporous Silica Nanoparticles: Types, Synthesis, Role in the Treatment of Alzheimer's Disease, and Other Applications.Pharmaceutics · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundActivities of daily living (ADL) are fundamental skills required to independently care for oneself and are categorized in basic (BADLs) and instrumental (IADLs) activities of daily living. ADL evaluation is of paramount importance in clinical practice to discriminate between healthy individuals (HC) and patients with mild cognitive impairment (MCI) or Alzheimer's disease (AD). However, it is unclear whether and to what extent BADL and IADL deficits occur in MCI, when compared with AD. Therefore, the present study aimed at comparing performance on both BADLs and IADLs in HC, MCI, and AD.
methodsThree electronic databases were consulted for studies comparing total BADLs/IADLs, and single BADLs/IADLs in AD, MCI, and HC (comparisons: AD versus MCI, AD versus HC, MCI versus HC). Ninety-six studies were included in the meta-analysis with random effect models (Hedges' g). Meta-regression was performed to evaluate the effect of clinical variables on ESs.
resultsAD group had more difficulties in BADLs and IADLs than HC and MCI groups; people with MCI showed more difficulties in both IADLs and BADLs than HC. The meta-regression analysis revealed that the percentage of males in the samples was a significant predictor of the ES in the meta-analysis comparing total BADL scores between MCI and HC; in the comparison between AD and HC, age at evaluation predicted the ES on some single IADLs: preparing food, handling medication, and finances.
conclusionsIn MCI, it should be considered not only a decline of IADLs but also subtle decline of BADL abilities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.