Evidence map›Paper›PMID 33738642›Full record

ArticleIntensive care medicine experimental2021

National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research.

Asher A Mendelson, Casey Lansdell, Alison E Fox-Robichaud, Patricia Liaw, Jaskirat Arora, Jean-François Cailhier, Gediminas Cepinskas, Emmanuel Charbonney, Claudia Dos Santos, Dhruva Dwivedi and 30 more

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 13 institutions in 2 countries.

Asher A MendelsonDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Casey LansdellRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Alison E Fox-RobichaudDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Patricia LiawDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Jaskirat AroraThrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada.
Jean-François CailhierCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
Gediminas CepinskasDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Emmanuel CharbonneyCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
Claudia Dos SantosKeenan Research Centre for Biomedical Science, Unity Health Toronto, Toronto, ON, Canada.
Dhruva DwivediDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Christopher G EllisDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Dean FergussonClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Kirsten FiestDepartment of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Sean E GillCentre for Critical Illness Research, Lawson Health Research Institute, London, ON, Canada.
Kathryn HendrickDepartment of Communications, Global Sepsis Alliance, Canada Sector, Toronto, ON, Canada.
Victoria T HunnifordClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Paulina M KowalewskaRobarts Research Institute, University of Western Ontario, London, ON, Canada.
Karla KrewulakDepartment of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Christian LehmannDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada.
Kimberly MacalaDepartment of Critical Care Medicine, Royal Alexandra Hospital, University of Alberta, Edmonton, AB, Canada.
John C MarshallKeenan Research Centre for Biomedical Science, Unity Health Toronto, Toronto, ON, Canada.
Laura MawdsleyDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Braedon McDonaldDepartment of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Ellen McDonaldDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Sarah K MedeirosThrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada.
Valdirene S MunizDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Marcin OsuchowskiLudwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.
Justin PresseauClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Neha SharmaThrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada.
Sahar SohrabipourThrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada.
Janet Sunohara-NeilsonAnimal Resources Centre, University Health Network, Toronto, ON, Canada.
Gloria Vázquez-GrandeDepartment of Internal Medicine, Section of Critical Care, University of Manitoba, Winnipeg, MB, Canada.
Ruud A W VeldhuizenCentre for Critical Illness Research, Lawson Health Research Institute, London, ON, Canada.
Donald WelshRobarts Research Institute, University of Western Ontario, London, ON, Canada.
Brent W WinstonSnyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Ryan ZarychanskiDepartment of Internal Medicine, Section of Critical Care, University of Manitoba, Winnipeg, MB, Canada.
Haibo ZhangKeenan Research Centre for Biomedical Science, Unity Health Toronto, Toronto, ON, Canada.
Juan ZhouDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada.
Manoj M LaluClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. mlalu@toh.ca.ORCID http://orcid.org/0000-0002-0322-382X
Sepsis Canada’s National Preclinical Sepsis Platform
Thrombosis and Atherosclerosis Research Institute · CAWestern University · CAOttawa Hospital · CAUniversity of Calgary · CAUniversity of Toronto · CACentre Hospitalier de l’Université de Montréal · CADalhousie University · CAUniversity of Manitoba · CADigital Research Alliance of CanadaLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA · ATUniversity Health Network · CAUniversity of Alberta · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation include poor representation by preclinical models of the complex human condition of sepsis, bias in preclinical studies, as well as limitations of single-laboratory methodology. To overcome some of these shortcomings, multicentre preclinical studies-defined as a research experiment conducted in two or more research laboratories with a common protocol and analysis-are expected to maximize transparency, improve reproducibility, and enhance generalizability. The ultimate objective is to increase the efficiency and efficacy of bench-to-bedside translation for preclinical sepsis research and improve outcomes for patients with life-threatening infection. To this end, we organized the first meeting of the National Preclinical Sepsis Platform (NPSP). This multicentre preclinical  research collaboration of Canadian sepsis researchers and stakeholders was established to study the pathophysiology of sepsis and accelerate movement of promising therapeutics into early phase clinical trials. Integrated knowledge translation and shared decision-making were emphasized to ensure the goals of the platform align with clinical researchers and patient partners. 29 participants from 10 independent labs attended and discussed four main topics: (1) objectives of the platform; (2) animal models of sepsis; (3) multicentre methodology and (4) outcomes for evaluation. A PIRO model (predisposition, insult, response, organ dysfunction) for experimental design was proposed to strengthen linkages with interdisciplinary researchers and key stakeholders. This platform represents an important resource for maximizing translational impact of preclinical sepsis research.

Indexed as

Experimental models of sepsisIntegrated knowledge translationMulticentre preclinicalMulti-stakeholderPIROReproducibilitySepsisTranslation

Identifiers

PMID33738642
PMCPMC7973346
OpenAlexW3137205406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.