ArticleBiomarkers in neuropsychiatry2020
Psychomotor Slowing in Schizophrenia: Implications for Endophenotype and Biomarker Development.
Article in Biomarkers in neuropsychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Schizophrenia and disordered sensorimotor control: challenges, mechanisms and opportunities.Brain : a journal of neurology · 2026Review
- Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study.Scientific reports · 2026Article
- Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation.Brain : a journal of neurology · 2026Review
- Handgrip and gait metrics as scalable markers of physical health in schizophrenia and alcohol use disorders.Global mental health (Cambridge, England) · 2026Article
- Impaired effort allocation in schizophrenia.Schizophrenia research. Cognition · 2025Article
- Testing a Motor Score Based on PANSS Ratings: A Proxy for Comprehensive Motor Assessment.Schizophrenia bulletin · 2025Article
- Reduced finger tapping speed in patients with schizophrenia and psychomotor slowing: an exploratory fMRI study.Frontiers in psychiatry · 2025Article
- Aberrant preparation of hand movement in schizophrenia spectrum disorder: an fMRI study.Brain communications · 2025Article
- Motor actions across psychiatric disorders: A research domain criteria (RDoC) perspective.Clinical psychology review · 2024Review
- Deciphering the interplay between psychopathological symptoms, sensorimotor, cognitive and global functioning: a transdiagnostic network analysis.European archives of psychiatry and clinical neuroscience · 2024Article
- Motor precision deficits in clinical high risk for psychosis.European archives of psychiatry and clinical neuroscience · 2024Article
- Isolation of Distinct Networks Driving Action and Cognition in Psychomotor Processes.Biological psychiatry · 2024Article
- The pathobiology of psychomotor slowing in psychosis: altered cortical excitability and connectivity.Brain : a journal of neurology · 2024Article
- Motor learning and performance in schizophrenia and aging: two different patterns of decline.Experimental brain research · 2024Article
- Intra- and inter-individual cognitive variability in schizophrenia and bipolar spectrum disorder: an investigation across multiple cognitive domains.Schizophrenia (Heidelberg, Germany) · 2023Article
- Neurodevelopmental vulnerability to psychosis: developmentally-based methods enable detection of early life inhibitory control deficits that predict psychotic-like experiences at the transition to adolescence.Psychological medicine · 2023Article
- Catatonia-like behavior and immune activation: a crosstalk between psychopathology and pathology in schizophrenia.Annals of general psychiatry · 2023Article
- Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2023Article
- The Behavioral Mapping of Psychomotor Slowing in Psychosis Demonstrates Heterogeneity Among Patients Suggesting Distinct Pathobiology.Schizophrenia bulletin · 2023Article
- Preserved electrophysiological markers of confidence in schizophrenia spectrum disorder.Schizophrenia (Heidelberg, Germany) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Motor abnormalities (e.g., dyskinesia, psychomotor slowing, neurological soft signs) are core features of schizophrenia that occur independent of drug treatment and are associated with the genetic vulnerability and pathophysiology for the illness. Among this list, psychomotor slowing in particular is one of the most consistently observed and robust findings in the field. Critically, psychomotor slowing may serve as a uniquely promising endophenotype and/or biomarker for schizophrenia considering it is frequently observed in those with genetic vulnerability for the illness, predicts transition in subjects at high-risk for the disorder, and is associated with symptoms and recovery in patients. The purpose of the present review is to provide an overview of the history of psychomotor slowing in psychosis, discuss its possible neural underpinnings, and review the current literature supporting slowing as a putative endophenotype and/or biomarker for the illness. This review summarizes substantial evidence from a diverse array of methodologies and research designs that supports the notion that psychomotor slowing not only reflects genetic vulnerability, but is also sensitive to disease processes and the pathophysiology of the illness. Furthermore, there are unique deficits across the cognitive (prefix "psycho") and motor execution (root word "motor") aspects of slowing, with cognitive processes such as planning and response selection being particularly affected. These findings suggest that psychomotor slowing may serve as a promising endophenotype and biomarker for schizophrenia that may prove useful for identifying individuals at greatest risk and tracking the course of the illness and recovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.