Evidence map›Paper›PMID 33738446›Full record

ArticleNeuro-oncology advances

[

Sean S Mahase, Diana A Roth O'Brien, Diana No, Michelle Roytman, Myrto E Skafida, Eaton Lin, Nicolas A Karakatsanis, Joseph R Osborne, Andrew Brandmaier, Susan C Pannullo and 4 more

Open access · goldAbstract read
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Trial
  4. Molecular Brain Tumor Imaging Beyond [AJR. American journal of roentgenology · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Combined SSTR2-targeted Analogue withFrontiers in oncology · 2026
    Article
  9. Article
  10. SUV-max ofJournal of neuro-oncology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Annals of nuclear medicine · 2024
    Article
  18. The use of PET/MRI in radiotherapy.Insights into imaging · 2024
    Review
  19. Somatostatin Receptor-PET/CT/MRI of Head and Neck Neuroendocrine Tumors.AJNR. American journal of neuroradiology · 2023
    Article
  20. Peptides for trans-blood-brain barrier delivery.Journal of labelled compounds & radiopharmaceuticals · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Sean S MahaseDepartment of Radiation Oncology, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0003-3488-6981
Diana A Roth O'BrienDepartment of Radiation Oncology, Weill Cornell Medicine, New York, New York, USA.
Diana NoDepartment of Radiation Oncology, Weill Cornell Medicine, New York, New York, USA.
Michelle RoytmanDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Myrto E SkafidaDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Eaton LinDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Nicolas A KarakatsanisDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Joseph R OsborneDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Andrew BrandmaierDepartment of Radiation Oncology, Weill Cornell Medicine, New York, New York, USA.
Susan C PannulloDepartment of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0001-6947-1837
Rohan RamakrishnaDepartment of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA.
Philip E StiegDepartment of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-8414-8277
Jonathan P S KniselyDepartment of Radiation Oncology, Weill Cornell Medicine, New York, New York, USA.
Jana IvanidzeDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-6470-5400
Cornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeningiomas express high levels of somatostatin receptor 2 (SSTR2). SSTR2-targeted PET imaging with [

methodsTwenty-nine patients underwent DOTATATE PET/MRI meningioma evaluation in 2019. Eight patients with 9 postoperative meningiomas met RTOG 0539 intermediate-risk criteria (recurrent WHO grade I, 1/9; WHO grade II, 8/9). Target volumes were created using DOTATATE PET/MRI to determine residual disease and received a nominal dose of 35.0 Gy over 5 fractions. For comparison, cases were recontoured and planned with MRI alone per RTOG 0539 guidelines. Mean and maximum equivalent 2 Gy doses were generated for target volumes and organs at risk (OAR) within 1 cm of the PTV and compared using Wilcoxon matched pairs signed rank test.

resultsDOTATATE PET/MRI-guided planning significantly reduced mean PTV (11.12 cm

conclusionIncorporating DOTATATE-PET/MRI for postoperative target delineation in patients with intermediate-risk intracranial meningiomas results in PTV reduction and decreased OAR dose. Our findings warrant larger studies evaluating DOTATATE-PET/MRI in the radiotherapeutic planning of postoperative meningiomas.

Indexed as

[68Ga]-DOTATATE PET/MRImeningiomaradiosurgerysomatostatin receptor 2

Identifiers

PMID33738446
PMCPMC7954102
OpenAlexW3124053874

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.