Evidence map›Paper›PMID 33738281›Full record

ArticleFrontiers in cell and developmental biology2021

Cell Surface Processing of CD109 by Meprin β Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles.

Wiebke Lückstädt, Simon Bub, Tomas Koudelka, Egor Pavlenko, Florian Peters, Prasath Somasundaram, Christoph Becker-Pauly, Ralph Lucius, Friederike Zunke, Philipp Arnold

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Antagonist nanobodies prevent protease inhibition by CD109.The Journal of biological chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Wiebke LückstädtAnatomical Institute, Christian-Albrechts-University Kiel, Kiel, Germany.
Simon BubAnatomical Institute, Christian-Albrechts-University Kiel, Kiel, Germany.
Tomas KoudelkaSystematic Proteomics and Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-University Kiel, Kiel, Germany.
Egor PavlenkoCenter for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Florian PetersLab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Schlieren, Switzerland.
Prasath SomasundaramSystematic Proteomics and Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-University Kiel, Kiel, Germany.
Christoph Becker-PaulyBiochemical Institute, Christian-Albrechts-University Kiel, Kiel, Germany.
Ralph LuciusAnatomical Institute, Christian-Albrechts-University Kiel, Kiel, Germany.
Friederike ZunkeDepartment of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany.
Philipp ArnoldAnatomical Institute, Christian-Albrechts-University Kiel, Kiel, Germany.
Kiel University · DEUniversitätsklinikum Erlangen · DEUniversity of Cologne · DEUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cluster of differentiation 109 (CD109) is a glycosylphosphatidylinositol (GPI)-anchored protein expressed on primitive hematopoietic stem cells, activated platelets, CD4

Indexed as

CD109exosomesextracellular vesiclesmacroglobulinmeprin βTEMTEP1r

Identifiers

PMID33738281
PMCPMC7960916
OpenAlexW3134402266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.