Evidence map›Paper›PMID 33738246›Full record

ArticleFrontiers in oncology2021

Predictive Value of Combined Preoperative Carcinoembryonic Antigen Level and Ki-67 Index in Patients With Gastric Neuroendocrine Carcinoma After Radical Surgery.

Jianwei Xie, YaJun Zhao, Yanbing Zhou, Qingliang He, Hankun Hao, Xiantu Qiu, Gang Zhao, Yanchang Xu, Fangqin Xue, Jinping Chen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Jianwei XieDepartment of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
YaJun ZhaoWest District of The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, China.
Yanbing ZhouDepartment of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, China.
Qingliang HeDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Hankun HaoHuashan Hospital, Fudan University, Shanghai, China.
Xiantu QiuDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Putian University, Putian, China.
Gang ZhaoRenji Hospital, Shanghai Jiaotong University, Shanghai, China.
Yanchang XuFujian Medicine University Teaching Hospital, The First Hospital of Putian, Putian, China.
Fangqin XueProvincial Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fujian, China.
Jinping ChenDepartment of Gastrointestinal Surgery, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China.
Guoqiang SuDepartment of Gastrointestinal Surgery, Xiamen Cancer Center, First Affiliated Hospital of Xiamen University, Xiamen, China.
Ping LiDepartment of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Chao-Hui ZhengDepartment of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Chang-Ming HuangDepartment of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Union Hospital · CNFujian Medical University · CNPutian University · CNFirst Affiliated Hospital of Fujian Medical University · CNFirst Affiliated Hospital of Xiamen University · CNFudan University · CNQingdao University · CNRenji Hospital · CNUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PRÉCIS: We present a valid and reproducible nomogram that combined the TNM stage as well as the Ki-67 index and carcinoembryonic antigen levels; the nomogram may be an indispensable tool to help predict individualized risks of death and help clinicians manage patients with gastric neuroendocrine carcinoma.

backgroundTo analyze the long-term outcomes of patients with grade 3 GNEC who underwent curative surgery and investigated whether the combination of carcinoembryonic antigen (CEA) levels and Ki-67 index can predict the prognosis of patients with gastric neuroendocrine carcinoma (GNEC) and constructed a nomogram to predict patient survival.

methodsIn the training cohort, data were collected from 405 patients with GNEC after radical surgery at seven Chinese centers. A nomogram was constructed to predict long-term prognosis. Data for the validation cohort were collected from 305 patients.

resultsThe 5-year overall survival (OS) was worse in the high CEA group than in the normal CEA group (40.5% vs. 55.2%, p = 0.013). The 5-year OS was significantly worse in the high Ki-67 index group than in the low Ki-67 index group (47.9% vs. 57.2%, p = 0.012). Accordingly, we divided the whole cohort into a KC(-) group (low Ki-67 index and normal CEA) and KC(+) group (high Ki-67 index and/or high CEA). The KC(+) group had a worse prognosis than the KC(-) group (64.6% vs. 46.8%, p < 0.001). KC(+) and the AJCC 8

conclusionsThe nomogram based on KC status and the AJCC 8

Indexed as

carcinoembryonic antigen (CEA)gastric neuroendocrine carcinomaKi-67nomogramprognosis

Identifiers

PMID33738246
PMCPMC7962601
OpenAlexW3133964042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.