Evidence map›Paper›PMID 33738124›Full record

ArticleVirus evolution2021

SARS-CoV-2 genomic analyses in cancer patients reveal elevated intrahost genetic diversity.

Juliana D Siqueira, Livia R Goes, Brunna M Alves, Pedro S de Carvalho, Claudia Cicala, James Arthos, João P B Viola, Andréia C de Melo, Marcelo A Soares

Open access · goldAbstract read
In one paragraph

Article in Virus evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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  16. SARS-CoV-2 Virology.Infectious disease clinics of North America · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Juliana D SiqueiraPrograma de Oncovirologia, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20.231-050, Brazil.ORCID https://orcid.org/0000-0002-4266-9795
Livia R GoesPrograma de Oncovirologia, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20.231-050, Brazil.
Brunna M AlvesPrograma de Oncovirologia, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20.231-050, Brazil.
Pedro S de CarvalhoPrograma de Oncovirologia, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20.231-050, Brazil.
Claudia CicalaLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
James ArthosLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
João P B ViolaPrograma de Imunologia e Biologia de Tumores, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20.231-050, Brazil.
Andréia C de MeloDivisão de Pesquisa Clínica e Desenvolvimento Tecnológico, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20.231-050, Brazil.
Marcelo A SoaresPrograma de Oncovirologia, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20.231-050, Brazil.
Instituto Nacional de Câncer - INCA · BRNational Institute of Allergy and Infectious Diseases · US

Funding

The Glycan Shield of the SARS-Cov-2 Spike; Antigenicity and FunctionZIAAI001273 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ARTHOS, JAMES L · 2020 to 2023
$392k
Intramural NIH HHS ZIA AI001273
6 · The paper itself

Abstract

Numerous factors have been identified to influence susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and disease severity. Cancer patients are more prone to clinically evolve to more severe COVID-19 conditions, but the determinants of such a more severe outcome remain largely unknown. We have determined the full-length SARS-CoV-2 genomic sequences of cancer patients and healthcare workers (non-cancer controls) by deep sequencing and investigated the within-host viral population of each infection, quantifying intrahost genetic diversity. Naso- and oropharyngeal SARS-CoV-2

Indexed as

cancerCOVID-19full-length genomeSARS-CoV-2single nucleotide variant

Identifiers

PMID33738124
PMCPMC7928633
OpenAlexW3133474571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.