Evidence map›Paper›PMID 33737950›Full record

ReviewFrontiers in genetics2021

Spliceosomal snRNA Epitranscriptomics.

Pedro Morais, Hironori Adachi, Yi-Tao Yu

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 110 citations in OpenAlex.

  1. Article
  2. Article
  3. SnoRNA Expression and RNA 2'-O-Methylation inbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Synthetic short RNA in cancer.Frontiers in oncology · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Pedro MoraisProQR Therapeutics, Leiden, Netherlands.
Hironori AdachiDepartment of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester Medical Center, Rochester, NY, United States.
Yi-Tao YuDepartment of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester Medical Center, Rochester, NY, United States.
University of Rochester Medical Center · USProQR Therapeutics (Netherlands) · NL

Funding

Pseudouridine-mediated branch site recognition/selection during pre-mRNA splicingR01GM138387 · NIGMS · UNIVERSITY OF ROCHESTER · PI YU, YI-TAO · 2020 to 2023
$1.4M
Suppression of disease causingnonsense mutations by targeted mRNA pseudouridylationR21CA241111 · NCI · UNIVERSITY OF ROCHESTER · PI YU, YI-TAO · 2019 to 2020
$368k
NCI NIH HHS R21 CA241111NIGMS NIH HHS R01 GM138387
6 · The paper itself

Abstract

Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell nucleus. snRNPs participate in pre-mRNA splicing by recognizing the critical sequence elements present in the introns, thereby forming active spliceosomes. The recognition is achieved primarily by base-pairing interactions (or nucleotide-nucleotide contact) between snRNAs and pre-mRNA. Notably, snRNAs are extensively modified with different RNA modifications, which confer unique properties to the RNAs. Here, we review the current knowledge of the mechanisms and functions of snRNA modifications and their biological relevance in the splicing process.

Indexed as

2'-O-methylationepitranscriptomicsN2-methylationN6-methyladenosinepre-mRNA splicingpseudouridineRNA modificationssmall nuclear RNA

Identifiers

PMID33737950
PMCPMC7960923
OpenAlexW3133844279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.