Evidence map›Paper›PMID 33737930›Full record

ReviewFrontiers in immunology2021

Translational Research in Vitiligo.

Erica L Katz, John E Harris

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Vitiligo Information Resource database v3.NPJ systems biology and applications · 2026
    Article
  3. Psychopharmacology in Dermatology.Indian dermatology online journal · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Markers of Metabolic Abnormalities in Vitiligo Patients.International journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Vitiligo: Pathogenesis and New and Emerging Treatments.International journal of molecular sciences · 2023
    Review
  15. Review
  16. How Does Vitamin D Affect Immune Cells Crosstalk in Autoimmune Diseases?International journal of molecular sciences · 2023
    Review
  17. Article
  18. Review
  19. Review
  20. Resident Memory T Cells in Psoriasis: Key to a Cure?Journal of psoriasis and psoriatic arthritis · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Erica L KatzDepartment of Medicine, Division of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States.
John E HarrisDepartment of Medicine, Division of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States.
University of Massachusetts Chan Medical School · US

Funding

Treg Migration and Function During Autoimmunity within Peripheral TissueR01AR069114 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HARRIS, JOHN E · 2015 to 2020
$2.2M
Dissecting autoimmune cellular and molecular networks in vitiligoR61AR073042 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GARBER, MANUEL, HARRIS, JOHN E · 2017 to 2018
$838k
Dissecting autoimmune cellular and molecular networks in vitiligoR33AR073042 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GARBER, MANUEL, HARRIS, JOHN E · 2019 to 2019
$419k
NIAMS NIH HHS R01 AR069114NIAMS NIH HHS R33 AR073042NIAMS NIH HHS R61 AR073042
6 · The paper itself

Abstract

Vitiligo is a disease of the skin characterized by the appearance of white spots. Significant progress has been made in understanding vitiligo pathogenesis over the past 30 years, but only through perseverance, collaboration, and open-minded discussion. Early hypotheses considered roles for innervation, microvascular anomalies, oxidative stress, defects in melanocyte adhesion, autoimmunity, somatic mosaicism, and genetics. Because theories about pathogenesis drive experimental design, focus, and even therapeutic approach, it is important to consider their impact on our current understanding about vitiligo. Animal models allow researchers to perform mechanistic studies, and the development of improved patient sample collection methods provides a platform for translational studies in vitiligo that can also be applied to understand other autoimmune diseases that are more difficult to study in human samples. Here we discuss the history of vitiligo translational research, recent advances, and their implications for new treatment approaches.

Indexed as

MelanocytesSkinSkin PigmentationTranslational Research, BiomedicalVitiligoAnimalsAutoimmunityDermatologic AgentsDisease Models, AnimalGenetic TestingHumansOxidative StressPhenotypeDermatologic Agentsautoimmunitygeneticsmelanocyte oxidative stresstranslational researchvitiligo

Identifiers

PMID33737930
PMCPMC7962476
OpenAlexW3135896946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.