ReviewJournal of pain research2021
Peripherally Induced Reconditioning of the Central Nervous System: A Proposed Mechanistic Theory for Sustained Relief of Chronic Pain with Percutaneous Peripheral Nerve Stimulation.
Review in Journal of pain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05649917 (A Post-Market Observational Case Series Study of Percutaneous Peripheral Nerve Stimulation), which is not on this map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Post-Market Observational Case Series Study of Percutaneous Peripheral Nerve Stimulation (PNS) for the Treatment of Chronic Shoulder Pain
Who cites it
57 citing papers in PubMed, 83 citations in OpenAlex.
- Comparison of percutaneous 60-day peripheral nerve stimulation of the lumbar medial branches to usual care with standard interventional management for chronic low back pain-a multicenter pragmatic randomized controlled trial (RESET).Pain medicine (Malden, Mass.) · 2026Trial
- Safety and Efficacy of Axon Therapy (SEAT Study), Utilizing Magnetic Peripheral Nerve Stimulation (mPNS) for Treatment of Neuropathic Pain.Journal of pain research · 2024Trial
- Investigation into the Effectiveness of Combining Transcranial Direct Current Stimulation and Transcutaneous Electrical Nerve Stimulation as Treatment Options for Poststroke Shoulder Pain by Utilizing Functional Near-Infrared Spectroscopy.Therapeutics and clinical risk management · 2023Trial
- Trial
- Durable Outcomes and Intervention Avoidance in Low Back Pain Up to 5 Years After Percutaneous 60-Day Peripheral Nerve Stimulation.Pain and therapy · 2026Article
- The Evolving Role of Peripheral Nerve Stimulation in Postoperative Analgesia and Recovery.Current pain and headache reports · 2026Review
- Peripheral Nerve Stimulation of C2-C3 Nerves for Management of Headaches: A Description of a Novel Technique.Current pain and headache reports · 2026Review
- Sustained relief of chronic headache using percutaneous 60-day peripheral nerve stimulation treatment: 12-month results from a multicenter, prospective clinical study.Interventional pain medicine · 2026Article
- Observations from the RESET clinical trial: A post-hoc per protocol analysis of clinical outcomes with percutaneous 60-day medial branch PNS in chronic low back pain.Interventional pain medicine · 2026Article
- Peripheral nerve stimulation targeting the trochanteric branch of the femoral nerve for refractory greater trochanteric pain syndrome followed by dorsal root ganglion stimulation: A case report and mechanistic perspective.Interventional pain medicine · 2026Article
- Mechanisms of Action of Low-Frequency Pulsed Magnetic Fields in Pain Control.Bioengineering (Basel, Switzerland) · 2026Review
- Predictors of Success for 60-Day Peripheral Nerve Stimulation Used for Treatment of Chronic Shoulder Pain: A Multicenter Retrospective Chart Review.American journal of physical medicine & rehabilitation · 2026Article
- Electromagnetic neuromodulation for chronic pain: historical context, contemporary modalities, and evidence gaps.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Article
- Evidence of Multifidus Changes Post-Lumbar Radiofrequency Ablation: A Narrative Literature Review.Journal of clinical medicine · 2025Review
- Long term management of refractory angina due to cardiac syndrome X with peripheral nerve field stimulation (PNfS).Interventional pain medicine · 2025Article
- Temporary Peripheral Nerve Stimulation (PNS) of the Cervical Medial Branch Nerve (CMBN) for Chronic Axial Neck Pain-A Literature Review and Case Series.Journal of clinical medicine · 2025Review
- Durable Shoulder Pain Relief and Avoidance of Surgery Up To 5 Years Following 60-Day PNS Treatment.Pain and therapy · 2025Article
- Targeted Interventional Therapies for the Management of Postamputation Pain: A Comprehensive Review.Biomedicines · 2025Review
- Four-Year Follow-Up from a Prospective, Multicenter Study of Percutaneous 60-Day Peripheral Nerve Stimulation for Chronic Low Back Pain.Pain and therapy · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral nerve stimulation (PNS) is an effective tool for the treatment of chronic pain, although its efficacy and utilization have previously been significantly limited by technology. In recent years, purpose-built percutaneous PNS devices have been developed to overcome the limitations of conventional permanently implanted neurostimulation devices. Recent clinical evidence suggests clinically significant and sustained reductions in pain can persist well beyond the PNS treatment period, outcomes that have not previously been observed with conventional permanently implanted neurostimulation devices. This narrative review summarizes mechanistic processes that contribute to chronic pain, and the potential mechanisms by which selective large diameter afferent fiber activation may reverse these changes to induce a prolonged reduction in pain. The interplay of these mechanisms, supported by data in chronic pain states that have been effectively treated with percutaneous PNS, will also be discussed in support of a new theory of pain management in neuromodulation: Peripherally Induced Reconditioning of the Central Nervous System (CNS).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.