ArticleClinical interventions in aging2021
Gene Set Index Based on Different Modules May Help Differentiate the Mechanisms of Alzheimer's Disease and Vascular Dementia.
Article in Clinical interventions in aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Single-Nucleus Landscape of Glial Cells and Neurons in Alzheimer's Disease.Molecular neurobiology · 2025Article
- Chemokines play a role in nerve damage and neuroprotection in vascular dementia.IBRO neuroscience reports · 2024Review
- Downregulation of miR-181c-5p in Alzheimer's disease weakens the response of microglia to Aβ phagocytosis.Scientific reports · 2024Article
- Identification of altered immune cell types and molecular mechanisms in Alzheimer's disease progression by single-cell RNA sequencing.Frontiers in aging neuroscience · 2024Article
- Exploration of novel biomarkers in Alzheimer's disease based on four diagnostic models.Frontiers in aging neuroscience · 2023Article
- Exploring Early Physical Examination Diagnostic Biomarkers for Alzheimer's Disease Based on Least Absolute Shrinkage and Selection Operator.Computational and mathematical methods in medicine · 2022Article
- Potential biomarkers of Alzheimer's disease and cerebral small vessel disease.Frontiers in molecular neuroscience · 2022Article
- Identification of molecular signatures associated with sleep disorder and Alzheimer's disease.Frontiers in psychiatry · 2022Article
- REPS1 as a Potential Biomarker in Alzheimer's Disease and Vascular Dementia.Frontiers in aging neuroscience · 2022Article
- Identification of Alzheimer's Disease Molecular Subtypes Based on Parallel Large-Scale Sequencing.Frontiers in aging neuroscience · 2022Article
- Microglia Mediate the Occurrence and Development of Alzheimer's Disease Through Ligand-Receptor Axis Communication.Frontiers in aging neuroscience · 2021Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlzheimer's disease (AD) and vascular dementia shared similar symptoms, the aim of the present study was to identify potential differences in the mechanisms underlying the two diseases. MATERIALS AND
methodsThe data set including AD, vascular dementia, and control samples was carried out gene differential expression analysis, weighted gene co-expression network analysis, functional enrichment, protein-protein interaction network construction, and least absolute shrinkage and selection operator analysis to reveal the differences in the mechanisms underlying the two diseases and potential diagnostic gene signature.
resultsWe identified the gene modules related to AD or vascular dementia. Enrichment analysis of module genes and construction of a protein-protein interaction network suggested that the "brown" module may be involved in a chemokine pathway, the "blue" module may be involved in cortisol synthesis and secretion, and the "turquoise" module may be involved in cholinergic synapse transmission. The hub gene-based signature index may be a biomarker of AD and vascular dementia and may even differentiate the two diseases from each other with high area under curve.
conclusionOur results identified not only core pathways involved in both AD and vascular disease, but also their potentially specific pathways. We proposed the hub gene-based signature index may be useful for diagnosing AD and vascular dementia.
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