Evidence map›Paper›PMID 33737747›Full record

ArticleNature microbiology2021

Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans.

Caroline A Werlang, Wesley G Chen, Kazuhiro Aoki, Kelsey M Wheeler, Carly Tymm, Cassidy J Mileti, Ana C Burgos, Kris Kim, Michael Tiemeyer, Katharina Ribbeck

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. α2-3-Sialylated Glycoproteins AttenuateInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Supramolecular Carbohydrate Assemblies with Tunable Glycan Surfaces.Angewandte Chemie (International ed. in English) · 2026
    Article
  5. Regulation of drug resistance and virulence ofFrontiers in microbiology · 2026
    Article
  6. Review
  7. Article
  8. Article
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  10. Article
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  15. Review
  16. Article
  17. Article
  18. Article
  19. [Research Progress on Drug Intervention to Inhibit Dental Plaque Biofilm Formation bySichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Caroline A WerlangDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-7554-8431
Wesley G ChenDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Kazuhiro AokiComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0003-0029-4291
Kelsey M WheelerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Carly TymmDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Cassidy J MiletiDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2093-157X
Ana C BurgosDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Kris KimDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1762-5982
Michael TiemeyerComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. ribbeck@mit.edu.ORCID http://orcid.org/0000-0001-8260-338X
Massachusetts Institute of Technology · USUniversity of Georgia · USDana-Farber Cancer Institute · USHarvard University · USJohnson & Johnson (United States) · USLoyola University Medical Center · US

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 1985 to 2020
$25.6M
Interdepartmental Biotechnology Training ProgramT32GM008334 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WITTRUP, KARL DANE · 1989 to 2018
$15.2M
GlyGen Supplement: Develop automatic literature mining tool for extracting context specific glycan-protein data that will enhance the extent and quality of data in GlyGenU01GM125267 · NIGMS · UNIVERSITY OF GEORGIA · PI MAZUMDER, RAJA, TIEMEYER, MICHAEL · 2017 to 2021
$10.2M
Mucin Glycans in the Regulation of Microbial VirulenceR01EB017755 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RIBBECK, KATHARINA · 2013 to 2022
$3.6M
NIBIB NIH HHS R01 EB017755NIEHS NIH HHS P30 ES002109NIGMS NIH HHS T32 GM008334NIGMS NIH HHS U01 GM125267
6 · The paper itself

Abstract

Mucus barriers accommodate trillions of microorganisms throughout the human body while preventing pathogenic colonization

Indexed as

Quorum SensingDental CariesHost-Pathogen InteractionsHumansMucin-5BPolysaccharidesSalivaStreptococcus mutansTransformation, BacterialVirulenceMUC5B protein, humanMucin-5BPolysaccharides

Identifiers

PMID33737747
PMCPMC8811953
OpenAlexW3139173313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.