Evidence map›Paper›PMID 33737712›Full record

ArticleScientific reports2021

Suppressor of cytokine signaling-1 mimetic peptides attenuate lymphocyte activation in the MRL/lpr mouse autoimmune model.

Jatin Sharma, Teresa D Collins, Tracoyia Roach, Shiwangi Mishra, Brandon K Lam, Zaynab Sidi Mohamed, Antia E Veal, Timothy B Polk, Amari Jones, Caleb Cornaby and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Jatin Sharma *Department of Microbiology & Cell Science, University of Florida, Museum Road Building 981, PO Box 110700, Gainesville, FL, 32611, USA.
Teresa D Collins *Department of Microbiology & Cell Science, University of Florida, Museum Road Building 981, PO Box 110700, Gainesville, FL, 32611, USA.
Tracoyia RoachDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.
Shiwangi MishraDepartment of Microbiology & Cell Science, University of Florida, Museum Road Building 981, PO Box 110700, Gainesville, FL, 32611, USA.
Brandon K LamDepartment of Microbiology & Cell Science, University of Florida, Museum Road Building 981, PO Box 110700, Gainesville, FL, 32611, USA.
Zaynab Sidi MohamedDepartment of Microbiology & Cell Science, University of Florida, Museum Road Building 981, PO Box 110700, Gainesville, FL, 32611, USA.
Antia E VealDepartment of Microbiology & Cell Science, University of Florida, Museum Road Building 981, PO Box 110700, Gainesville, FL, 32611, USA.
Timothy B PolkDepartment of Microbiology & Cell Science, University of Florida, Museum Road Building 981, PO Box 110700, Gainesville, FL, 32611, USA.
Amari JonesDepartment of Microbiology & Cell Science, University of Florida, Museum Road Building 981, PO Box 110700, Gainesville, FL, 32611, USA.
Caleb CornabyDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.
Mohammed I HaiderDepartment of Microbiology & Cell Science, University of Florida, Museum Road Building 981, PO Box 110700, Gainesville, FL, 32611, USA.
Leilani Zeumer-SpataroDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.
Howard M JohnsonDepartment of Microbiology & Cell Science, University of Florida, Museum Road Building 981, PO Box 110700, Gainesville, FL, 32611, USA.
Laurence M MorelDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.
Joseph LarkinDepartment of Microbiology & Cell Science, University of Florida, Museum Road Building 981, PO Box 110700, Gainesville, FL, 32611, USA. jlarkin3@ufl.edu.
University of Florida · USFlorida Museum of Natural History · US

Funding

SF2UF: A new Bridges Baccalaureate program between Santa Fe College and the University of Florida.R25GM115298 · NIGMS · UNIVERSITY OF FLORIDA · PI JULIAN, DAVID, MOODY, VERTIGO · 2015 to 2019
$1.3M
NIGMS NIH HHS R25 GM115298
6 · The paper itself

Abstract

Autoimmune diseases are driven largely by a pathogenic cytokine milieu produced by aberrantly activated lymphocytes. Many cytokines, including interferon gamma (IFN-γ), utilize the JAK/STAT pathway for signal propagation. Suppressor of Cytokine Signaling-1 (SOCS1) is an inducible, intracellular protein that regulates IFN-γ signaling by dampening JAK/STAT signaling. Using Fas deficient, MRL/MpJ-Fas

Indexed as

AnimalsAutoimmune DiseasesBiomimeticsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesfas ReceptorForkhead Transcription FactorsInterferon-gammaJanus KinasesLupus Erythematosus, SystemicLymph NodesLymphocytesMiceMice, Inbred MRL lprCytokinesFas protein, mousefas ReceptorForkhead Transcription FactorsFoxp3 protein, mouseIFNG protein, humanInterferon-gammaJanus KinasesPeptidesSTAT Transcription FactorsSuppressor of Cytokine Signaling 1 Protein

Identifiers

PMID33737712
PMCPMC7973732
OpenAlexW3138671928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.