Evidence map›Paper›PMID 33737707›Full record

ArticleScientific reports2021

The effects of myelin on macrophage activation are phenotypic specific via cPLA

Timothy J Kopper, Bei Zhang, William M Bailey, Kara E Bethel, John C Gensel

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Arachidonic acid metabolism in spinal cord injury.Journal of advanced research · 2026
    Review
  3. Article
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  5. Article
  6. Nanoparticle and epothilone D combinatorial intervention improves motor performance and regeneration in chronic cervical spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Functions and mechanisms of cytosolic phospholipase ANeural regeneration research · 2023
    Review
  16. Article
  17. Regulation of microglia function by neural stem cells.Frontiers in cellular neuroscience · 2023
    Review
  18. Article
  19. Clickable Biomaterials for Modulating Neuroinflammation.International journal of molecular sciences · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Timothy J KopperDepartment of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
Bei ZhangDepartment of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
William M BaileyDepartment of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
Kara E BethelDepartment of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
John C GenselDepartment of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA. gensel.1@uky.edu.
University of Kentucky · US

Funding

Neurobiology of CNS Injury and RepairT32NS077889 · NINDS · UNIVERSITY OF KENTUCKY · PI Warren Joseph Alilain, JOHN C GENSEL · 2012 to 2026
$2.4M
The role of macrophage phenotype and age in spinal cord injuryR01NS091582 · NINDS · UNIVERSITY OF KENTUCKY · PI GENSEL, JOHN C · 2015 to 2019
$1.6M
Contributions of Myelin Derived Arachidonic Acid to Macrophage Polarization and Secondary Damage after Spinal Cord InjuryF31NS105443 · NINDS · UNIVERSITY OF KENTUCKY · PI KOPPER, TIMOTHY JOSEPH · 2018 to 2020
$90k
NINDS NIH HHS F31 NS105443NINDS NIH HHS R01 NS091582NINDS NIH HHS T32 NS077889
6 · The paper itself

Abstract

Spinal cord injury (SCI) produces chronic, pro-inflammatory macrophage activation that impairs recovery. The mechanisms driving this chronic inflammation are not well understood. Here, we detail the effects of myelin debris on macrophage physiology and demonstrate a novel, activation state-dependent role for cytosolic phospholipase-A2 (cPLA

Indexed as

AnimalsCytokinesDisease Models, AnimalFemaleHumansInflammationInterleukin-4KetonesLipidsMacrophage ActivationMiceMicrogliaMyelin SheathNitric OxidePhagocytosisPhenotypeCytokinesInterleukin-4KetonesLipidsNitric Oxidepalmitoyl trifluoromethyl ketonePhospholipases A2, CytosolicReactive Oxygen Species

Identifiers

PMID33737707
PMCPMC7973514
OpenAlexW3136028281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.