ArticleScientific reports2021
Relationships between oxygen changes in the brain and periphery following physiological activation and the actions of heroin and cocaine.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Brain oxygen responses induced by arousing stimuli and fentanyl: generalized or structure-specific?American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- The role of central versus peripheral opioid receptors in fentanyl-induced brain hypoxia.Journal of neurophysiology · 2026Article
- Hypoxic effects of heroin and fentanyl and their basic physiological mechanisms.American journal of physiology. Lung cellular and molecular physiology · 2024Review
- Oxygen fluctuations in the brain and periphery induced by intravenous fentanyl: effects of dose and drug experience.Journal of neurophysiology · 2024Article
- Combined treatment with naloxone and the alpha2 adrenoceptor antagonist atipamezole reversed brain hypoxia induced by a fentanyl-xylazine mixture in a rat model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Brain oxygen responses induced by opioids: focus on heroin, fentanyl, and their adulterants.Frontiers in psychiatry · 2024Review
- Neurovascular effects of cocaine: relevance to addiction.Frontiers in pharmacology · 2024Review
- Xylazine effects on opioid-induced brain hypoxia.Psychopharmacology · 2023Article
- The pattern of brain oxygen response induced by intravenous fentanyl limits the time window of therapeutic efficacy of naloxone.Neuropharmacology · 2023Article
- Basic metabolic and vascular effects of ketamine and its interaction with fentanyl.Neuropharmacology · 2023Article
- Basic physiological effects of ketamine-xylazine mixture as a general anesthetic preparation for rodent surgeries.Brain research · 2023Article
- Rapid fluctuations in brain oxygenation during glucose-drinking behavior in trained rats.Journal of neurophysiology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Using two-sensor electrochemical recordings in freely moving rats, we examined the relationship between physiological and drug-induced oxygen fluctuations in the brain and periphery. Animals chronically implanted with oxygen sensors in the nucleus accumbens (NAc) and subcutaneous (SC) space were subjected to several mildly arousing stimuli (sound, tail-pinch and social interaction) and intravenous injections of cocaine and heroin. Arousing stimuli induced rapid increases in NAc oxygen levels followed by and correlated with oxygen decreases in the SC space. Therefore, cerebral vasodilation that increases cerebral blood flow and oxygen entry into brain tissue results from both direct neuronal activation and peripheral vasoconstriction, which redistributes arterial blood from periphery to the brain. The latter factor could also explain a similar pattern of oxygen responses found in the substantia nigra reticulata, suggesting hyperoxia as a global phenomenon with minor structural differences during early time intervals following the stimulus onset. While arousing stimuli and cocaine induced similar oxygen responses in the brain and SC space, heroin induced a biphasic down-up brain oxygen fluctuation associated with a monophasic oxygen decrease in the SC space. Oxygen decreases occurred more rapidly and stronger in the SC space, reflecting a drop in blood oxygen levels due to respiratory depression.
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